Nonsynonymous Single-Nucleotide Variations on Some Posttranslational Modifications of Human Proteins and the Association with Diseases

Figure 6

The cross talks between the ubiquitylation site K326 of protein TOP1 with other PTM sites on TP53. Green lines show the association of K326 with other PTM sites based on the evidence of coevolution. Some domains on the two proteins are also given, largely boxed in blue and grey. The different PTMs boxed in red show disease-related PTM sites and those with more than one kind of PTM on the same residue were boxed in black.