Optimal Control Strategy for Abnormal Innate Immune Response

Figure 2

Optimal controls under three different strategies. Black solid lines, in (a), (b), and (c), represent the dimensionless concentration of viral mRNAs (), IFNs (), and AVPs () without treatment, respectively. Dashed blue line, green dotted line, and red dotted line represent the control effect about , , and under Strategy 1 (only control ), Strategy 2 (only control ), and Strategy 3 (control and ), respectively. (d) shows the control functions under the different control methods, in which the red triangle dotted line and squares dotted lines represent control strength of and when and are joint action. (e) shows dimensionless costs under the different iterations. All parameters and initial conditions are taken from Table 1.

(a)

(b)

(c)

(d)

(e)