Research Article

The Influence of DNA Configuration on the Direct Strand Break Yield

Table 1

Dimensions of the main DNA structures for the three configurations studied in this work. Most of these data were extracted from [7]. The target volumes were determined according to these dimensions and the geometrical model used (see [18] for details). All dimensions are shown in nm, unless otherwise stated.

Features DNA configurations
A B Z

Helix orientation Right-handed Right-handed Left-handed
DNA diameter 2.55 2.37 1.84
bp diameter 1.0 1.0 0.6
bp axial step 0.23 0.33 0.38
Helix pitch 2.46 3.2 3.0
bp/helix turn 10.7 10 12
bp/nucleosome 286 198 172
Helix axial shift 0.76 1.2 0.77
Target angular aperture 87° 73° 60°
Target height 0.119 0.183 0.249
Total number of bp
Target volume (nm3) 0.12 0.13 0.10