In Silico Design of Human IMPDH Inhibitors Using Pharmacophore Mapping and Molecular Docking Approaches

Table 4

The evaluation of ligand-based pharmacophore model using the Güner-Henry scoring method.

	Hypo-03	Hypo-04	Hypo-07	Hypo-08
Total number of molecules in the decoy set ()	729	729	729	729
Total number of actives in the decoy set ()	20	20	20	20
Active hits ()	20	20	20	15
Total hits ()	66	75	35	54
Yield of actives (%)	100%	100%	100%	75%
Hit rate of actives (%)	30.30%	26.67%	57.14%	27.78%
Enrichment factor ()	11.05	9.72	20.83	10.13
Goodness of hit score (GH)	0.45	0.41	0.67	0.50

GH: Güner-Henry.