Identifying New Candidate Genes and Chemicals Related to Prostate Cancer Using a Hybrid Network and Shortest Path Approach

Table 1

The top six KEGG pathways shared by 187 significant candidate genes.

Pathway ID	Pathway name	Genes sharing the pathway	FDR
hsa05200	Pathways in cancer	FGF6, FGFR2, TRAF2, FGFR1, PDGFB, WNT3A, MITF, NFKB1, TGFB1, CTNNB1, GLI1, MAX, WNT1, CASP3, RARA, HHIP, AXIN1, PIK3R2, CREBBP, CDK6, BIRC2, RALGDS, CCND1, PLCG1, NTRK1, MAPK3, PDGFRB, PTCH1, IKBKB, and GSTP1
hsa04010	MAPK signaling pathway	FGFR2, FGF6, TRAF2, FGFR1, PDGFB, PPP3R1, NFKB1, TGFB1, ATF2, MAP3K7, MAX, TNFRSF1A, CASP3, MAP3K5, MAP3K3, MAP2K6, RASA1, FLNA, MAPK14, NTRK1, GADD45G, MAPK3, PDGFRB, HSPB1, IKBKB, CD14, and DUSP6
hsa05215	Prostate cancer	FGFR2, FGFR1, CCND1, PDGFB, MAPK3, CREBBP, PDGFRB, NFKB1, IKBKB, GSTP1, CTNNB1, and PIK3R2
hsa05214	Glioma	CCND1, PLCG1, PDGFB, CAMK2G, MAPK3, PDGFRB, CDK6, SHC1, CALM2, and PIK3R2
hsa04722	Neurotrophin signaling pathway	CAMK2G, NFKB1, MAGED1, MAP3K5, MAP3K3, PLCG1, NTRK1, MAPK14, MAPK3, SHC1, IKBKB, CALM2, and PIK3R2
hsa04310	Wnt signaling pathway	ROCK1, WNT3A, CAMK2G, CREBBP, CSNK2B, PPP3R1, CTNNB1, MAP3K7, WNT1, CCND1, CSNK1E, LRP6, LRP5, and AXIN1