Performance Enhancement of Pharmacokinetic Diffuse Fluorescence Tomography by Use of Adaptive Extended Kalman Filtering

Figure 1

Two-compartmental model of ICG pharmacokinetics. and denote the tissue concentrations of ICG in plasma and EES, that is, the numbers of ICG molecules in plasma and EES relative to the total tissue volume, respectively, , , and are pharmacokinetic-rates describing the ICG leakage into and the drainage out of the EES, as well as the ICG elimination from the body through circulatory system, respectively, is the arterial input function (AIF), and is volume flow.