The Structural Characterization of Tumor Fusion Genes and Proteins

Figure 1

A multistep process of the formation of fusion proteins. A novel fusion gene is formed after two fusion partner genes A (pink) and B (blue) break at their breakpoints. The black points in the fusion partner genes and novel fusion gene represent the breakpoint. The fusion gene translates into a fusion protein, which has three domains, domain a (dark blue) from fusion partner protein a, domain b (cyan) from the fusion partner protein b, and a connection domain (orange).