Boolean Modeling of Cellular and Molecular Pathways Involved in Influenza Infection

Figure 1

Signaling pathways’ and transcription factors’ (TFs) activities in response to IV infections: activities estimated by QuSAGE [20] using genome-wide expression profiles measured upon infections of DCs with NC virus, in comparison with mock-infected DCs. Activities are of (a) ligand induced signaling pathways from BIOCARTA database and (b) TFs using binding sites available in MSigDB [21] (rows), across time (-axis). Coloring represents downregulated (yellow) to upregulated (blue) activity relative to the preinfection time point.

(a)

(b)