Periodically Pulsed Immunotherapy in a Mathematical Model of Tumor, CD4⁺ T Cells, and Antitumor Cytokine Interactions

Table 1

Parameters, biological meanings, and units.

Parameter	Biological meaning	Unit
	Intrinsic growth rate of the tumor
	Carrying capacity of the tumor
	Maximum tumor killing rate by antitumor cytokine
	Half saturation constant of the tumor killing rate
	Maximum T cell production rate (antigenicity of the tumor)
	Half saturation constant of T cell production rate
	Death rate of the T cells
	Maximum production rate of the antitumor cytokine
	Half saturation constant of antitumor cytokine production rate
	Antitumor cytokine loss rate
	Treatment of T cells
	Treatment of cytokine (IL-4)