Hemoglobin-Dilution Method: Effect of Measurement Errors on Vascular Volume Estimation

Figure 1

A histogram of computed initial blood volume (BV) estimates assuming an error-free BV of 5 L for normally distributed measurement errors of 0.5, 1, and 2% SD is shown. The solid circles are histogram counts of the number of error occurrences (10,000 total) which fall in the 0.2 l wide bins for the 1% SD added error as computed with an Excel spreadsheet. The solid line is a log-normal (LN) fit to these data. The thin- and thick-dashed lines are fits to the 0.5 and 2% added error data (not shown), respectively. The arrows indicate the bounds for 68.3% of the potential errors ( to ) for the 1% SD case, where is the geometric mean value and is the dispersion factor (see text) for the LN distribution.