Utilizing Selected Di- and Trinucleotides of siRNA to Predict RNAi Activity

Table 1

Primary dinucleotides with minimal value.

Position	Dinucleotide motif	Freq; ()	Freq; ()	Type of corr.	value
1	UU1	178/1218	25/1213	Positive
	GG1	36/1218	159/1213	Negative
2	UA2	73/1218	32/1213	Positive
	GC2	48/1218	96/1213	Negative
3	AA3	76/1218	53/1213	Positive
	CC3	57/1218	91/1213	Negative
4	UU4	111/1218	69/1213	Positive
	CC4	60/1218	107/1213	Negative
5	AU5	94/1218	56 /1213	Positive
	CC5	66/1218	102/1213	Negative
6	UU6	117/1218	63/1213	Positive
	CC6	47/1218	110/1213	Negative
7	UU7	104/1218	67/1213	Positive
	CA7	70/1218	120/1213	Negative
8	CG8	32/1218	51/1213	Negative
9	CA9	108/1218	66/1213	Positive
	GU9	56/1218	84/1213	Negative
10	AU10	101/1218	62/1213	Positive
	CC10	63/1218	96/1213	Negative
11	AA11	74/1218	46/1213	Positive
	GG11	78/1218	111/1213	Negative
12	CG12	32/1218	56/1213	Negative
13	AU13	108/1218	65/1213	Positive
	GG13	59/1218	114/1213	Negative
14	UU14	105/1218	72/1213	Positive
	GG14	60/1218	110/1213	Negative
15	CA15	113/1218	74/1213	Positive
	GG15	72/1218	108/1218	Negative
16	AC16	82/1218	46/1213	Positive
	GG16	68/1218	137/1213	Negative
17	AC17	80/1218	45/1213	Positive
	GA17	51/1218	95/1213	Negative
18	UC18	114/1218	69/1213	Positive
	AA18	29/1218	87/1213	Negative
19	CU19	124/1218	53/1213	Positive
	AC19	30/1218	63/1213	Negative
20	UG20	146/1218	67/1213	Positive
	CC20	52/1218	101/1213	Negative