Utilizing Selected Di- and Trinucleotides of siRNA to Predict RNAi Activity

<table class="table-group" id="tab4"><tr><td><table class="table"><tr><td class="thead-hr" colspan="2"><hr/></td></tr><tr class="thead"><td class="align_left">Method</td><td class="align_center">PCC (<svg height="6.1673pt" id="M216" style="vertical-align:-0.2063904pt" version="1.1" viewbox="-0.0498162 -5.96091 5.60619 6.1673" width="5.60619pt" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink"><g transform="matrix(.013,0,0,-0.013,0,0)"><path d="M393 379C402 394 400 411 393 422C384 437 365 448 348 448C301 448 237 372 186 285H182L193 335C210 408 205 448 178 448C150 448 80 402 29 344L45 321C80 355 114 373 122 373C128 373 130 365 124 330C106 228 76 98 50 -5L57 -12C82 -5 112 3 132 6L172 203C196 256 234 304 254 329C275 355 293 367 306 367C318 367 330 360 342 348C347 343 355 343 365 350S386 367 393 379Z" id="g113-115"></path><glyph.data ascent="3473" descent="-2876" horiz-adv-x="422" vert-adv-y="422"></glyph.data></g></svg>)</td></tr><tr><td class="thead-hr" colspan="2"><hr/></td></tr><tr><td class="align_left">Biopredsi</td><td class="align_center">0.660</td></tr><tr><td class="align_left"><svg height="8.8423pt" id="M217" style="vertical-align:-0.2064009pt" version="1.1" viewbox="-0.0498162 -8.6359 3.66193 8.8423" width="3.66193pt" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink"><g transform="matrix(.013,0,0,-0.013,0,0)"><path d="M244 607C244 633 228 655 200 655C166 655 146 618 146 594C146 564 166 546 191 546C221 546 244 574 244 607ZM222 91L209 114C184 94 148 66 133 66C127 66 124 73 130 96L201 370C213 416 211 448 191 448C162 448 88 407 29 352L42 328C73 354 104 371 114 371C120 371 119 365 115 345L53 92C32 5 45 -12 68 -12C103 -12 186 50 222 91Z" id="g113-106"></path><glyph.data ascent="3473" descent="-2876" horiz-adv-x="273" vert-adv-y="273"></glyph.data></g></svg>-score</td><td class="align_center">0.654</td></tr><tr><td class="align_left">ThermoComposition-21</td><td class="align_center">0.659</td></tr><tr><td class="align_left">DSIR</td><td class="align_center">0.670</td></tr><tr><td class="align_left"><i>siRNApred</i></td><td class="align_center"><i>0.722</i></td></tr><tr class="table-tr"><td colspan="2"><hr class="tbody-hr"/></td></tr></table></td></tr></table>

PCC between observed and predicted siRNA activities for five algorithms.

Computational and Mathematical Methods in Medicine

tab4

Table 4

Table 4: Utilizing Selected Di- and Trinucleotides of siRNA to Predict RNAi Activity 