Estimating and Interpreting Effects from Nonlinear Exposure-Response Curves in Occupational Cohorts Using Truncated Power Basis Expansions and Penalized Splines

<div>Estimated exposure-response curves on the natural logarithmic scale (logarithm of the hazard ratio) for simulated data with 41 cases in 500 observations (a, b, c) and with 40 cases in 5000 observations (d, e, f) using linear, linear splines, and linear B-splines (a, d), cubic spline and cubic B-splines (b, e), and penalized splines (c, f).</div>

Computational and Mathematical Methods in Medicine

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Figure 10: Estimating and Interpreting Effects from Nonlinear Exposure-Response Curves in Occupational Cohorts Using Truncated Power Basis Expansions and Penalized Splines 

Figure 10 | Estimating and Interpreting Effects from Nonlinear Exposure-Response Curves in Occupational Cohorts Using Truncated Power Basis Expansions and Penalized Splines 