Computing Individual Risks Based on Family History in Genetic Disease in the Presence of Competing Risks

Figure 4

Posterior probabilities for the carrier genotypes of each individual (Individuals 1 to 12) in our hypothetical family (Figure 1). The posterior probability of being a paternal carrier and a maternal carrier ) is colored in black and in grey, respectively. The deleterious allele being very rare in the general population (), the probability of the monozygous carrier genotype is almost zero for each individual and it is therefore not represented here.