Association between ERCC1 Gene Polymorphism (rs11615) and Colorectal Cancer Susceptibility: A Meta-Analysis of Medical Image Fusion and Safety Applications

Table 2

Summary of ORs (95% CI) with heterogeneity test for ERCC1 rs11615 polymorphism and CRC cancer risk under several genetic models.

Subgroup	No. of studies	T vs. C		TT + TC vs. CC		TT vs. TC + CC	I^2	TT vs. CC
		OR (95% CI)		OR (95% CI)		OR (95% CI)		OR (95% CI)
Racial descent
Asian	4	1.19 (1.05-1.35)^b	0	1.19 (1.00-1.41)^b	0	1.36 (1.06-1.73)^b	28	1.43 (1.10-1.85)^b	16.7
Caucasian	5	1.08 (0.97-1.21)	0	1.09 (0.90-1.32)	0	1.11 (0.94-1.32)	0.7	1.16 (0.92-1.46)	0
Source of control
Population-based	2	1.10 (0.85-1.42)	60^a	1.01 (0.76-1.34)	11.6	1.17 (0.85-1.62)	52.4^a	1.14 (0.71-1.82)	50.7^a
Hospital-based	7	1.16 (1.05-1.29)^b	0	1.18 (1.03-1.36)^b	0	1.24 (1.03-1.50)^b	18.5	1.37 (1.12-1.70)^b	0
HWE
<0.05	2	1.20 (0.96-1.50)	50.1^a	1.16 (0.93-1.44)	0	1.43 (0.91-2.26)	60.3^a	1.46 (0.91-2.35)	57.1^a
≥ 7.1	7	1.10 (1.00-1.22)	0	1.14 (0.97-1.33)	0	1.12 (0.96-1.32)	0	1.19 (0.97-1.47)	0
Overall	9	1.13 (1.04-1.23)^b	0	1.14 (1.01-1.30)^b	0	1.19 (1.03-1.37)^b	18.8	1.27 (1.07-1.51)^b	3.3

^a: Random effect estimate. ^b: Significant results, .