Robust Nonnegative Matrix Factorization via Joint Graph Laplacian and Discriminative Information for Identifying Differentially Expressed Genes

Table 4

Cholangiocarcinoma genes extracted by GLD-RNMF.

Gene ID	Gene name	Gene annotations	Relative diseases
213	ALB	Enzyme binding and chaperone binding.	Analbuminemia and congenital analbuminemia
3240	HP	Serine-type endopeptidase activity and hemoglobin binding	Anhaptoglobinemia and plasmodium falciparum malaria
5265	SERPINA1	Identical protein binding and protease binding	Emphysema due to Aat deficiency and alpha 1-antitrypsin deficiency
718	C3	Receptor binding and C5L2 anaphylatoxin chemotactic receptor binding	Macular degeneration, age-related, 9, and C3 deficiency
2243	FGA	Receptor binding and protein binding, bridging	Dysfibrinogenemia, congenital, and afibrinogenemia, congenital
7448	VTN	Heparin binding and scavenger receptor activity	Glanzmann thrombasthenia and camptodactyly-arthropathy-coxa vara-pericarditis syndrome.
7018	TF	Ubiquitin protein ligase binding and ferric iron transmembrane transporter activity	Atransferrinemia and iron overload In Africa
335	APOA1	Identical protein binding and lipid binding	Amyloidosis, familial visceral, and hypoalphalipoproteinemia