Critical Analysis of Electromagnetic Hyperthermia Randomized Trials: Dubious Effect and Multiple Biases

Table 15

Final record of randomized clinical trials on hyperthermia in oncology.

Type	Authors	Year	Localization	Sponsor	Conclusion
					Resume	Estimation
Superficial HT	Kapp et al. [7]	1990	Superficial	Independent	No significant effect	Negative
	Perez et al. [5]	1991	Superficial	Independent	No significant effect	Negative
	Emami et al. [8]	1992	Superficial	Independent	No significant effect	Negative
	Engin et al. [9]	1993	Superficial	Independent	No significant effect	Negative
	Vernon et al. [10]	1996	Superficial	Hyperthermic	Significant Effect	Dubious
	Overgaard et al. [11]	1996	Melanoma	Hyperthermic	Significant Effect	Clinically insignificant
	Jones et al. [12]	2005	Superficial	Hyperthermic	Significant Effect	Dubious
Deep HT	Emami et al. [20]	1996	Deep seated	Independent	No significant effect	Negative
		2000	Rectum	Hyperthermic	No significant effect	Negative
	van der Zee et al. [21]		Bladder		No significant effect	Negative
			Cervix		Significant effect	Clinically insignificant
	Harima et al. [24]	2001	Cervix	Hyperthermic	Significant effect	Dubious
	Vasanthan et al. [15]	2005	Cervix	Independent	No significant effect	Extremely negative
	Mitsumori et al. [22]	2007	NSCLC	Independent	No significant effect	Negative
	Issels et al. [23]	2010	ST sarcomas	Hyperthermic	Significant effect	Dubious
WBH	Bakhshandeh et al. [40]	2004	Pleural mesothelioma	Hyperthermic	No significant effect	Extremely negative