Conference Paper
Critical Analysis of Electromagnetic Hyperthermia Randomized Trials: Dubious Effect and Multiple Biases
Table 2
Clinical results of Vernon et al. trial [
10].
| | DHG | MRC BrI | MRC BrR | ESHO | PMH | TOTAL | RT | TRT | RT | TRT | RT | TRT | RT | TRT | RT | TRT | RT | TRT |
| Total | 19 | 19 | 12 | 18 | 59 | 90 | 29 | 27 | 16 | 17 | 135 | 171 |
| CR | 14 | 14 | 8 | 10 | 17 | 51 | 11 | 21 | 5 | 5 | 55 | 101 | % | 74c | 74% | 67% | 56% | 29% | 57% | 38% | 78% | 31% | 29% | 41% | 59% | Difference | 0% | −11% | 28% | 40% | −2% | 18% | OR | 1 | 0,65 | 3,23 | 5,73 | 0,92 | 2,3 | Local recurrence after CR | 6 | 3 | 0 | 1 | 6 | 3 | 4 | 8 | 1 | 2 | 17 | 17 | % | 32% | 16% | 0% | 6% | 10% | 3% | 14% | 30% | 6% | 12% | 13% | 10% | Difference | −16% | 6% | −7% | 16% | 6% | −3% | Progression elsewhere | 9 | 11 | 2 | 3 | 12 | 42 | 7 | 18 | 1 | 1 | 31 | 75 | % | 47% | 58% | 17% | 17% | 20% | 47% | 24% | 67% | 6% | 6% | 23% | 44% | Difference | 11% | 0% | 26% | 43% | 0% | 21% | Dead | 2 | 6 | 2 | 4 | 9 | 36 | 3 | 6 | 0 | 0 | 16 | 52 | % | 11% | 32% | 17% | 22% | 15% | 40% | 10% | 22% | 0% | 0% | 12% | 30% | Difference | 21% | 6% | 25% | 12% | 0% | 19% |
| No CR | 5 | 5 | 4 | 8 | 42 | 39 | 18 | 8 | 11 | 12 | 80 | 70 | % | 26% | 26% | 33% | 44% | 71% | 43% | 62% | 30% | 69% | 71% | 59% | 41% | Difference | 0% | 11% | −28% | −32% | 2% | −18% | Progression elsewhere | 5 | 3 | 4 | 5 | 33 | 31 | 14 | 5 | 10 | 11 | 66 | 55 | % | 26% | 16% | 33% | 28% | 56% | 34% | 48% | 19% | 63% | 65% | 49% | 32% | Difference | −11% | −6% | −21% | −30% | 2% | −17% | Dead | 4 | 3 | 4 | 5 | 35 | 36 | 9 | 4 | 6 | 6 | 58 | 54 | % | 21% | 16% | 33% | 28% | 59% | 40% | 31% | 15% | 38% | 35% | 43% | 32% | Difference | −5% | −6% | −19% | −16% | −2% | −11% |
| All patients | | | | | | | | | | | | | Actuarial survival at 2 years | 12 | 13 | 15 | 12 | 6 | 5 | 11 | 10 | 17 | 13 | 5 | 4 | % | 65% | 62% | 48% | 44% | 32% | 21% | 42% | 68% | 46% | 59% | 41% | 36% | Difference | −3% | −4% | −11% | 26% | 13% | −5% | Progression elsewhere | 14 | 14 | 6 | 8 | 45 | 73 | 21 | 23 | 11 | 12 | 97 | 130 | % | 74% | 74% | 50% | 44% | 76% | 81% | 72% | 85% | 69% | 71% | 72% | 76% | Difference | 0% | −6% | 5% | 13% | 2% | 4% | Dead | 6 | 9 | 6 | 9 | 44 | 72 | 12 | 10 | 6 | 6 | 74 | 106 | % | 32% | 47% | 50% | 50% | 75% | 80% | 41% | 37% | 38% | 35% | 55% | 62% | Difference | 16% | 0% | 5% | −4% | −2% | 7% |
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