All the processed and HE stained tumor samples in this study. Morphologically the first significant sign of cell destruction was seen 8 h after the treatment. Drastic and selective tumor destruction was detected 24 h after OTM which became more emphasized after 48 h. 72 hours after the treatment a significant leucocyte infiltration (marked with red arrows) appeared around the destructed tumor tissue and reached its maximum 168 hours after the treatment.
