Role of Hypertension in Aggravating A𝛽 Neuropathology of AD Type and Tau-MediatedMotor Impairment

Figure 1

Experimentally induced hypertension significantly elevated the blood pressure of Tg 2576 and P301L-tau Tg mice. (a), (c) Experimental hypertension had no aversive effect on body weight of mice versus normotensive control group. (b), (d) Experimental hypertension progressively elevated BP as shown by systolic, diastolic and mean arterial pressure (MAP). Values represent mean ± SEM values. (a), (b) 𝑛=6 mice per group. (c), (d) 𝑛=10 mice per group. Differences between means were analyzed using two-tailed Student’s 𝑡 test versus control normotensive mice, ^∗𝑃<.05 , ^∗∗∗𝑃<.0001 by two-tailed Student's 𝑡 test analysis.

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