Forebrain Ischemia Triggers GABAergic System Degeneration in Substantia Nigra at Chronic Stages in Rats

Figure 2

Neurodegeneration in substantia nigra (SN) and striatum at day 56 following 12.5 minutes of transient global ischemia in rats (H&E staining). Eosinophilic and shrunken neurons (arrows) are present in SN ((a)–(c)). (b) is a magnified view of the boxed area in (a). Eosinophilic and shrunken neurons are adjacent to injured blood vessels (c). Striata show severe or moderate spongy changes ((d), (e)) which are proximate to abnormal perivascular area (e). The active astrocytes were detected by anti-GFAP in SN of sham rat (f) and in ischemia rat at day 56 (g). No astrogliosis was observed in both groups.

(a)

(b)

(c)

(d)

(e)

(f)

(g)