Forebrain Ischemia Triggers GABAergic System Degeneration in Substantia Nigra at Chronic Stages in Rats

Figure 7

Distribution of calretinin (CR) neurons through substantia nigra (SN) in coronal sections of rats at level ∼−5.3 mm to bregma at 56 days of survival. (a) In a sham rat, numerous CR-ir neurons were detected in pars compacta (SNC) and to a lesser extent in pars lateralis (SNL); (b) is the magnification of the boxed region in (a); the insert shows a higher magnification of neurons. (c)–(h) Calretinin immunoreactivity in six ischemic rats after a 12.5-minute period of global ischemia at day 56. The number of CR-neurons was reduced in the SN after ischemia.

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