- About this Journal
- Abstracting and Indexing
- Aims and Scope
- Article Processing Charges
- Articles in Press
- Author Guidelines
- Bibliographic Information
- Citations to this Journal
- Contact Information
- Editorial Board
- Editorial Workflow
- Free eTOC Alerts
- Publication Ethics
- Reviewers Acknowledgment
- Submit a Manuscript
- Subscription Information
- Table of Contents
Cardiovascular Psychiatry and Neurology
Volume 2011 (2011), Article ID 461263, 8 pages
Elucidating the Complex Interactions between Stress and Epileptogenic Pathways
1Department of Integrative Biology, University of California-Berkeley, Berkeley, CA 94720-3140, USA
2Institute of Neurophysiology, Charité University Medicine, 10117 Berlin, Germany
3Department of Psychiatry and Psychotherapy, Charité University Medicine, 10117 Berlin, Germany
4Helen Wills Neuroscience Institute, University of California-Berkeley, Berkeley, CA 94720-3140, USA
Received 13 November 2010; Accepted 22 January 2011
Academic Editor: Alon Friedman
Copyright © 2011 Aaron R. Friedman et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
- J. Dionisio and W. O. Tatum, “Triggers and techniques in termination of partial seizures,” Epilepsy and Behavior, vol. 17, no. 2, pp. 210–214, 2010.
- M. M. Frucht, M. Quigg, C. Schwaner, and N. B. Fountain, “Distribution of seizure precipitants among epilepsy syndromes,” Epilepsia, vol. 41, no. 12, pp. 1534–1539, 2000.
- M. R. Sperling, C. A. Schilling, D. Glosser, J. I. Tracy, and A. A. Asadi-Pooya, “Self-perception of seizure precipitants and their relation to anxiety level, depression, and health locus of control in epilepsy,” Seizure, vol. 17, no. 4, pp. 302–307, 2008.
- S. R. Haut, C. B. Hall, J. Masur, and R. B. Lipton, “Seizure occurrence: precipitants and prediction,” Neurology, vol. 69, no. 20, pp. 1905–1910, 2007.
- J. P. Shonkoff, W. T. Boyce, and B. S. McEwen, “Neuroscience, molecular biology, and the childhood roots of health disparities: building a new framework for health promotion and disease prevention,” Journal of the American Medical Association, vol. 301, no. 21, pp. 2252–2259, 2009.
- D. D. Francis, “Conceptualizing child health disparities: a role for developmental neurogenomics,” Pediatrics, vol. 124, no. 3, supplement, pp. S196–S202, 2009.
- B. S. McEwen, “Understanding the potency of stressful early life experiences on brain and body function,” Metabolism, vol. 57, no. 2, pp. S11–S15, 2008.
- B. S. McEwen, “Physiology and neurobiology of stress and adaptation: central role of the brain,” Physiological Reviews, vol. 87, no. 3, pp. 873–904, 2007.
- B. S. McEwen, “Stress, sex, and neural adaptation to a changing environment: mechanisms of neuronal remodeling,” Annals of the New York Academy of Sciences, vol. 1204, supplement, pp. E38–E59, 2010.
- C. F. Gillespie, J. Phifer, B. Bradley, and K. J. Ressler, “Risk and resilience: genetic and environmental influences on development of the stress response,” Depression and Anxiety, vol. 26, no. 11, pp. 984–992, 2009.
- D. Francis, J. Diorio, D. Liu, and M. J. Meaney, “Nongenomic transmission across generations of maternal behavior and stress responses in the rat,” Science, vol. 286, no. 5442, pp. 1155–1158, 1999.
- M. J. Meaney, J. Diorio, D. Francis et al., “Early environmental regulation of forebrain glucocorticoid receptor gene expression: implications for adrenocortical responses to stress,” Developmental Neuroscience, vol. 18, no. 1-2, pp. 49–72, 1996.
- D. L. Bellinger, C. Lubahn, and D. Lorton, “Maternal and early life stress effects on immune function: relevance to immunotoxicology,” Journal of Immunotoxicology, vol. 5, no. 4, pp. 419–444, 2008.
- A. Danese, C. M. Pariante, A. Caspi, A. Taylor, and R. Poulton, “Childhood maltreatment predicts adult inflammation in a life-course study,” Proceedings of the National Academy of Sciences of the United States of America, vol. 104, no. 4, pp. 1319–1324, 2007.
- N. Bazak, N. Kozlovsky, Z. Kaplan et al., “Pre-pubertal stress exposure affects adult behavioral response in association with changes in circulating corticosterone and brain-derived neurotrophic factor,” Psychoneuroendocrinology, vol. 34, no. 6, pp. 844–858, 2009.
- M. Lippmann, A. Bress, C. B. Nemeroff, P. M. Plotsky, and L. M. Monteggia, “Long-term behavioural and molecular alterations associated with maternal separation in rats,” European Journal of Neuroscience, vol. 25, no. 10, pp. 3091–3098, 2007.
- T. L. Roth, F. D. Lubin, A. J. Funk, and J. D. Sweatt, “Lasting Epigenetic Influence of Early-Life Adversity on the BDNF Gene,” Biological Psychiatry, vol. 65, no. 9, pp. 760–769, 2009.
- A. M. Karssen, S. Her, J. Z. Li et al., “Stress-induced changes in primate prefrontal profiles of gene expression,” Molecular Psychiatry, vol. 12, no. 12, pp. 1089–1102, 2007.
- B. A. Barres, M. A. Lazar, and M. C. Raff, “A novel role for thyroid hormone, glucocorticoids and retinoic acid in timing oligodendrocyte development,” Development, vol. 120, no. 5, pp. 1097–1108, 1994.
- R. P. Gobert, L. Joubert, M. L. Curchod et al., “Convergent functional genomics of oligodendrocyte differentiation identifies multiple autoinhibitory signaling circuits,” Molecular and Cellular Biology, vol. 29, no. 6, pp. 1538–1553, 2009.
- L. Joubert, I. Foucault, Y. Sagot et al., “Chemical inducers and transcriptional markers of oligodendrocyte differentiation,” Journal of Neuroscience Research, vol. 88, no. 12, pp. 2546–2557, 2010.
- S. A. Mann, B. Versmold, R. Marx et al., “Corticosteroids reverse cytokine-induced block of survival and differentiation of oligodendrocyte progenitor cells from rats,” Journal of Neuroinflammation, vol. 5, article no. 39, 2008.
- J. S. Meyer and K. R. Fairman, “Early adrenalectomy increases myelin content of the rat brain,” Brain Research, vol. 349, no. 1-2, pp. 1–9, 1985.
- W. L. Huang, C. G. Harper, S. F. Evans, J. P. Newnham, and S. A. Dunlop, “Repeated prenatal corticosteroid administration delays myelination of the corpus callosum in fetal sheep,” International Journal of Developmental Neuroscience, vol. 19, no. 4, pp. 415–425, 2001.
- S. Saltik, N. Kocer, and A. Dervent, “Magnetic resonance imaging findings in infantile spasms: etiologic and pathophysiologic aspects,” Journal of Child Neurology, vol. 18, no. 4, pp. 241–246, 2003.
- L. B. Jardim, R. F. Pires, C. E. Martins et al., “Pyridoxine-Dependent seizures associated with white matter abnormalities,” Neuropediatrics, vol. 25, no. 5, pp. 259–261, 1994.
- J. Silva, S. Sharma, B. Hughes, Y. E. Yu, and J. K. Cowell, “Homozygous inactivation of the Lgi1 gene results in hypomyelination in the peripheral and central nervous systems,” Journal of Neuroscience Research, vol. 88, no. 15, pp. 3328–3336, 2010.
- Y. E. Yu, L. Wen, J. Silva et al., “Lgi1 null mutant mice exhibit myoclonic seizures and CA1 neuronal hyperexcitability,” Human Molecular Genetics, vol. 19, no. 9, pp. 1702–1711, 2010.
- T. J. De Koning, M. Duran, L. Van Maldergem et al., “Congenital microcephaly and seizures due to 3-phosphoglycerate dehydrogenase deficiency: outcome of treatment with amino acids,” Journal of Inherited Metabolic Disease, vol. 25, no. 2, pp. 119–125, 2002.
- T. J. de Koning, J. Jaeken, M. Pineda, L. Van Maldergem, B. T. Poll-The, and M. S. Van der Knaap, “Hypomyelination and reversible white matter attenuation in 3-phosphoglycerate dehydrogenase deficiency,” Neuropediatrics, vol. 31, no. 6, pp. 287–292, 2000.
- A. G. Chapman, E. Westerberg, M. Premachandra, and B. S. Meldrum, “Changes in regional neurotransmitter amino acid levels in rat brain during seizures induced by L-allylglycine, bicuculline, and kainic acid,” Journal of Neurochemistry, vol. 43, no. 1, pp. 62–70, 1984.
- S. Meier, A. U. Bräuer, B. Heimrich, R. Nitsch, and N. E. Savaskan, “Myelination in the hippocampus during development and following lesion,” Cellular and Molecular Life Sciences, vol. 61, no. 9, pp. 1082–1094, 2004.
- C. Kendal, I. Everall, C. Polkey, and S. Al-Sarraj, “Glial cell changes in the white matter in temporal lobe epilepsy,” Epilepsy Research, vol. 36, no. 1, pp. 43–51, 1999.
- E. Hutchinson, D. Pulsipher, K. Dabbs et al., “Children with new-onset epilepsy exhibit diffusion abnormalities in cerebral white matter in the absence of volumetric differences,” Epilepsy Research, vol. 88, no. 2-3, pp. 208–214, 2010.
- T. Wang, L. Jia, B. Lv et al., “Human Ermin (hErmin), a new oligodendrocyte-specific cytoskeletal protein related to epileptic seizure,” Brain Research, vol. 1367, pp. 77–84, 2011.
- L. A. Mitchell, A. S. Harvey, L. T. Coleman, S. A. Mandelstam, and G. D. Jackson, “Anterior temporal changes on MR images of children with hippocampal sclerosis: an effect of seizures on the immature brain?” American Journal of Neuroradiology, vol. 24, no. 8, pp. 1670–1677, 2003.
- M. C. Lai, C. C. Lui, S. N. Yang, J. Y. Wang, and L. T. Huang, “Epileptogenesis is increased in rats with neonatal isolation and early-life seizure and ameliorated by MK-801: a long-term MRI and histological study,” Pediatric Research, vol. 66, no. 4, pp. 441–447, 2009.
- N. C. Jones, G. Kumar, T. J. O'Brien, M. J. Morris, S. M. Rees, and M. R. Salzberg, “Anxiolytic effects of rapid amygdala kindling, and the influence of early life experience in rats,” Behavioural Brain Research, vol. 203, no. 1, pp. 81–87, 2009.
- M. Salzberg, G. Kumar, L. Supit et al., “Early postnatal stress confers enduring vulnerability to limbic epileptogenesisy,” Epilepsia, vol. 48, no. 11, pp. 2079–2085, 2007.
- C. A. Frye, “Effects and mechanisms of progestogens and androgens in ictal activity,” Epilepsia, vol. 51, supplement 3, pp. 135–140, 2010.
- H. E. Scharfman and N. J. MacLusky, “The influence of gonadal hormones on neuronal excitability, seizures, and epilepsy in the female,” Epilepsia, vol. 47, no. 9, pp. 1423–1440, 2006.
- G. J. Ter Horst, R. Wichmann, M. Gerrits, C. Westenbroek, and Y. Lin, “Sex differences in stress responses: focus on ovarian hormones,” Physiology and Behavior, vol. 97, no. 2, pp. 239–249, 2009.
- T. R. Taher, M. Salzberg, M. J. Morris, S. Rees, and T. J. O'Brien, “Chronic low-dose corticosterone supplementation enhances acquired epileptogenesis in the rat amygdala kindling model of TLE,” Neuropsychopharmacology, vol. 30, no. 9, pp. 1610–1616, 2005.
- D. Kaufer, W. O. Ogle, Z. S. Pincus et al., “Restructuring the neuronal stress response with anti-glucocorticoid gene delivery,” Nature Neuroscience, vol. 7, no. 9, pp. 947–953, 2004.
- K. Dinkel, A. MacPherson, and R. M. Sapolsky, “Novel glucocorticoid effects on acute inflammation in the CNS,” Journal of Neurochemistry, vol. 84, no. 4, pp. 705–716, 2003.
- J. R. Caso, I. Lizasoain, P. Lorenzo, M. A. Moro, and J. C. Leza, “The role of tumor necrosis factor-alpha in stress-induced worsening of cerebral ischemia in rats,” Neuroscience, vol. 142, no. 1, pp. 59–69, 2006.
- J. R. Caso, M. A. Moro, P. Lorenzo, I. Lizasoain, and J. C. Leza, “Involvement of IL-1β in acute stress-induced worsening of cerebral ischaemia in rats,” European Neuropsychopharmacology, vol. 17, no. 9, pp. 600–607, 2007.
- L. P. Cacheaux, S. Ivens, Y. David et al., “Transcriptome profiling reveals TGF-β signaling involvement in epileptogenesis,” Journal of Neuroscience, vol. 29, no. 28, pp. 8927–8935, 2009.
- Y. David, L. P. Cacheaux, S. Ivens et al., “Astrocytic dysfunction in epileptogenesis: consequence of altered potassium and glutamate homeostasis?” Journal of Neuroscience, vol. 29, no. 34, pp. 10588–10599, 2009.
- S. Ivens, D. Kaufer, L. P. Flores et al., “TGF-β receptor-mediated albumin uptake into astrocytes is involved in neocortical epileptogenesis,” Brain, vol. 130, no. 2, pp. 535–547, 2007.
- H. S. Sharma, J. Cervos-Navarro, and P. K. Dey, “Increased blood-brain barrier permeability following acute short-term swimming exercise in conscious normotensive young rats,” Neuroscience Research, vol. 10, no. 3, pp. 211–221, 1991.
- D. Shlosberg, M. Benifla, D. Kaufer, and A. Friedman, “Blood-brain barrier breakdown as a therapeutic target in traumatic brain injury,” Nature Reviews Neurology, vol. 6, pp. 393–403, 2010.
- A. Friedman, D. Kaufer, J. Shemer, I. Hendler, H. Soreq, and I. Tur-Kaspa, “Pyridostigmine brain penetration under stress enhances neuronal excitability and induces early immediate transcriptional response,” Nature Medicine, vol. 2, no. 12, pp. 1382–1385, 1996.
- P. Esposito, D. Gheorghe, K. Kandere et al., “Acute stress increases permeability of the blood-brain-barrier through activation of brain mast cells,” Brain Research, vol. 888, no. 1, pp. 117–127, 2001.
- F. E. Dudek and T. P. Sutula, “Epileptogenesis in the dentate gyrus: a critical perspective,” Progress in Brain Research, vol. 163, pp. 755–773, 2007.
- N. C. de Lanerolle and T. S. Lee, “New facets of the neuropathology and molecular profile of human temporal lobe epilepsy,” Epilepsy and Behavior, vol. 7, no. 2, pp. 190–203, 2005.
- G. Seifert, G. Carmignoto, and C. Steinhäuser, “Astrocyte dysfunction in epilepsy,” Brain Research Reviews, vol. 63, no. 1-2, pp. 212–221, 2010.
- N. C. de Lanerolle, T. S. Lee, and D. D. Spencer , “Astrocytes and epilepsy,” Neurotherapeutics, vol. 7, pp. 424–438, 2010.
- P. F. Fabene, G. N. Mora, M. Martinello et al., “A role for leukocyte-endothelial adhesion mechanisms in epilepsy,” Nature Medicine, vol. 14, no. 12, pp. 1377–1383, 2008.
- S. F. Sorrells, J. R. Caso, C. D. Munhoz, and R. M. Sapolsky, “The stressed CNS: when glucocorticoids aggravate inflammation,” Neuron, vol. 64, no. 1, pp. 33–39, 2009.
- J. L. M. Madrigal, O. Hurtado, M. A. Moro et al., “The increase in TNF-α levels is implicated in NF-κB activation and inducible nitric oxide synthase expression in brain cortex after immobilization stress,” Neuropsychopharmacology, vol. 26, no. 2, pp. 155–163, 2002.
- J. L.M. Madrigal, M. A. Moro, I. Lizasoain et al., “Inducible nitric oxide synthase expression in brain cortex after acute restraint stress is regulated by nuclear factor κB-mediated mechanisms,” Journal of Neurochemistry, vol. 76, no. 2, pp. 532–538, 2001.
- J. L. M. Madrigal, M. A. Moro, I. Lizasoain et al., “Induction of cyclooxygenase-2 accounts for restraint stress-induced oxidative status in rat brain,” Neuropsychopharmacology, vol. 28, no. 9, pp. 1579–1588, 2003.
- B. García-Bueno, J. L. M. Madrigal, B. G. Pérez-Nievas, and J. C. Leza, “Stress mediators regulate brain prostaglandin synthesis and peroxisome proliferator-activated receptor-γ activation after stress in rats,” Endocrinology, vol. 149, no. 4, pp. 1969–1978, 2008.
- R. Kuruba, B. Hattiangady, and A. K. Shetty, “Hippocampal neurogenesis and neural stem cells in temporal lobe epilepsy,” Epilepsy and Behavior, vol. 14, no. 1, supplement, pp. 65–73, 2009.
- H. E. Scharfman and D. P. McCloskey, “Postnatal neurogenesis as a therapeutic target in temporal lobe epilepsy,” Epilepsy Research, vol. 85, no. 2-3, pp. 150–161, 2009.
- M. Joëls, “Role of corticosteroid hormones in the dentate gyrus,” Progress in Brain Research, vol. 163, pp. 355–370, 2007.
- D. T. Balu and I. Lucki, “Adult hippocampal neurogenesis: regulation, functional implications, and contribution to disease pathology,” Neuroscience and Biobehavioral Reviews, vol. 33, no. 3, pp. 232–252, 2009.
- C. Mirescu and E. Gould, “Stress and adult neurogenesis,” Hippocampus, vol. 16, no. 3, pp. 233–238, 2006.
- J. B. Aldenhoff, D. L. Gruol, and J. Rivier, “Corticotropin releasing factor decreases postburst hyperpolarizations and excites hippocampal neurons,” Science, vol. 221, no. 4613, pp. 875–877, 1983.
- J. Liu, B. Yu, V. Neugebauer et al., “Corticotropin-releasing factor and urocortin I modulate excitatory glutamatergic synaptic transmission,” Journal of Neuroscience, vol. 24, no. 16, pp. 4020–4029, 2004.
- G. S. Hollrigel, K. Chen, T. Z. Baram, and I. Soltesz, “The pro-convulsant actions of corticotropin-releasing hormone in the hippocampus of infant rats,” Neuroscience, vol. 84, no. 1, pp. 71–79, 1998.
- B. Roozendaal, G. Schelling, and J. L. McGaugh, “Corticotropin-releasing factor in the basolateral amygdala enhances memory consolidation via an interaction with the β-adrenoceptor-cAMP pathway: dependence on glucocorticoid receptor activation,” Journal of Neuroscience, vol. 28, no. 26, pp. 6642–6651, 2008.
- B. Moghaddam, M. L. Bolinao, B. Stein-Behrens, and R. Sapolsky, “Glucocorticoids mediate the stress-induced extracellular accumulation of glutamate,” Brain Research, vol. 655, no. 1-2, pp. 251–254, 1994.
- B. Moghaddam, “Stress preferentially increases extraneuronal levels of excitatory amino acids in the prefrontal cortex: comparison to hippocampus and basal ganglia,” Journal of Neurochemistry, vol. 60, no. 5, pp. 1650–1657, 1993.
- E. R. de Kloet, H. Karst, and M. Joëls, “Corticosteroid hormones in the central stress response: quick-and-slow,” Frontiers in Neuroendocrinology, vol. 29, no. 2, pp. 268–272, 2008.
- H. Karst, S. Berger, M. Turiault, F. Tronche, G. Schütz, and M. Joëls, “Mineralocorticoid receptors are indispensable for nongenomic modulation of hippocampal glutamate transmission by corticosterone,” Proceedings of the National Academy of Sciences of the United States of America, vol. 102, no. 52, pp. 19204–19207, 2005.
- H. Karst and M. Joëls, “Corticosterone slowly enhances miniature excitatory postsynaptic current amplitude in mice CA1 hippocampal cells,” Journal of Neurophysiology, vol. 94, no. 5, pp. 3479–3486, 2005.
- D. S. Kerr, L. W. Campbell, O. Thibault, and P. W. Landfield, “Hippocampal glucocorticoid receptor activation enhances voltage-dependent Ca conductances: relevance to brain aging,” Proceedings of the National Academy of Sciences of the United States of America, vol. 89, no. 18, pp. 8527–8531, 1992.
- P. Chameau, Y. Qin, S. Spijker, G. Smit, and M. Joëls, “Glucocorticoids specifically enhance L-type calcium current amplitude and affect calcium channel subunit expression in the mouse hippocampus,” Journal of Neurophysiology, vol. 97, no. 1, pp. 5–14, 2007.
- M. Joëls, “Stress, the hippocampus, and epilepsy,” Epilepsia, vol. 50, no. 4, pp. 586–597, 2009.