Effects of Neonatal Systemic Inflammation on Blood-Brain Barrier Permeability and Behaviour in Juvenile and Adult Rats
Figure 1
The sensory motor gaiting of animal cohorts was tested using the prepulse inhibition paradigm. Animals were exposed to a 115 dB stimulus either alone or with a 4, 8 or 16 dB prepulse. The presence of a prepulse inhibits the startle response produced by the 115 dB stimulus alone. Data are presented as percent startle inhibition (mean ± SEM) for each prepulse intensity. At P20 (a), animals exposed to LPS had reduced startle inhibition compared to saline-injected age-matched controls (**, linear regression analyses; ). Adult animals (b) showed no significant difference between groups of animals although there was a trend toward reduced startle inhibition at 16 dB prepulse in LPS-treated animals ( for each data point).
