The Etiological Role of Blood-Brain Barrier Dysfunction in Seizure Disorders

Figure 3

Leakage of the BBB is associated with neonatal seizures. (a) Summary of the neurovascular changes induced by prenatal exposure to MAM and/or THAL. (b) Seizures in neonatal THAL-MAM rats displayed on a joint time-frequency plot. Note also the traces recorded by the scalp electrode. (c) Loss of selective BBB permeability is associated to brain edema and hemispheric asymmetry in THAL-MAM rats. Red arrows point to region of disrupted cytoarchitecture due to vascular edema. (c1) FITC-albumin is used to indicate loss of BBB integrity.