615829.fig.002
Figure 2: Schematic diagram of the three-compartment model of tissue. EES: extravascular extracellular space; EIS: extravascular intracellular space; 𝜏 𝑏 1 : unidirectional rate constant for water extravasation; 𝐾 t r a n s : pseudo-first-order rate constant for CR extravasation.