The Blood-Brain Barrier and Microvascular Water Exchange in Alzheimer's Disease

<table>7 T (a) DCE-MRI maps of blood volume (<svg height="11.3125" id="M111" style="vertical-align:-3.2316pt" version="1.1" viewbox="0 0 13.8 11.3125" width="13.8" xmlns="http://www.w3.org/2000/svg">
<g transform="matrix(1.25,0,0,-1.25,0,11.3125)">
<g transform="translate(72,-62.95)">
<text transform="matrix(1,0,0,-1,-71.95,66.22)">
<tspan style="font-size: 12.50px; " x="0" y="0">𝑣</tspan>
</text>
<text transform="matrix(1,0,0,-1,-65.62,63.1)">
<tspan style="font-size: 8.75px; " x="0" y="0">𝑏</tspan>
</text>
</g>
</g>
</svg>) and water permeability (<svg height="14.575" id="M112" style="vertical-align:-3.21404pt" version="1.1" viewbox="0 0 29.762501 14.575" width="29.762501" xmlns="http://www.w3.org/2000/svg">
<g transform="matrix(1.25,0,0,-1.25,0,14.575)">
<g transform="translate(72,-60.34)">
<text transform="matrix(1,0,0,-1,-71.95,63.6)">
<tspan style="font-size: 12.50px; " x="0" y="0">𝑃</tspan>
</text>
<text transform="matrix(1,0,0,-1,-64.52,60.47)">
<tspan style="font-size: 8.75px; " x="0" y="0">𝑤</tspan>
</text>
<text transform="matrix(1,0,0,-1,-57.24,63.6)">
<tspan style="font-size: 12.50px; " x="0" y="0">𝑆</tspan>
</text>
</g>
</g>
</svg>) in a superior slice from a 71-year-old female with early AD [<a href="/journals/cpn/2011/615829/#B81">78</a>]. (b) <svg height="14.2375" id="M113" style="vertical-align:-3.13504pt" version="1.1" viewbox="0 0 14.8125 14.2375" width="14.8125" xmlns="http://www.w3.org/2000/svg">
<g transform="matrix(1.25,0,0,-1.25,0,14.2375)">
<g transform="translate(72,-60.61)">
<text transform="matrix(1,0,0,-1,-71.95,63.79)">
<tspan style="font-size: 12.50px; " x="0" y="0">𝑇</tspan>
</text>
<text transform="matrix(1,0,0,-1,-65.07,60.66)">
<tspan style="font-size: 8.75px; " x="0" y="0">2</tspan>
</text>
</g>
</g>
</svg>-weighted spin echo image and corresponding <svg height="11.05" id="M114" style="vertical-align:-3.2316pt" version="1.1" viewbox="0 0 13.5375 11.05" width="13.5375" xmlns="http://www.w3.org/2000/svg">
<g transform="matrix(1.25,0,0,-1.25,0,11.05)">
<g transform="translate(72,-63.16)">
<text transform="matrix(1,0,0,-1,-71.95,66.44)">
<tspan style="font-size: 12.50px; " x="0" y="0">𝑝</tspan>
</text>
<text transform="matrix(1,0,0,-1,-65.84,63.31)">
<tspan style="font-size: 8.75px; " x="0" y="0">𝑏</tspan>
</text>
</g>
</g>
</svg> map from a healthy 70-year-old female. Arrows indicate hyperintense white matter regions (15–23 mm<sup>2</sup>) visible on both the <svg height="14.2375" id="M115" style="vertical-align:-3.13504pt" version="1.1" viewbox="0 0 14.8125 14.2375" width="14.8125" xmlns="http://www.w3.org/2000/svg">
<g transform="matrix(1.25,0,0,-1.25,0,14.2375)">
<g transform="translate(72,-60.61)">
<text transform="matrix(1,0,0,-1,-71.95,63.79)">
<tspan style="font-size: 12.50px; " x="0" y="0">𝑇</tspan>
</text>
<text transform="matrix(1,0,0,-1,-65.07,60.66)">
<tspan style="font-size: 8.75px; " x="0" y="0">2</tspan>
</text>
</g>
</g>
</svg> image and corresponding parametric map.</table>

Cardiovascular Psychiatry and Neurology

fig4

Figure 4

Figure 4: The Blood-Brain Barrier and Microvascular Water Exchange in Alzheimer's Disease 