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Cardiovascular Psychiatry and Neurology
Volume 2012 (2012), Article ID 120540, 9 pages
http://dx.doi.org/10.1155/2012/120540
Research Article

Elevated Serum C-Reactive Protein Relates to Increased Cerebral Myoinositol Levels in Middle-Aged Adults

1Department of Psychology, The University of Texas at Austin, Austin, TX 78722, USA
2Imaging Research Center, The University of Texas at Austin, Austin, TX 78759, USA
3Department of Kinesiology and Health Education, The University of Texas at Austin, Austin, TX 78712, USA

Received 31 July 2011; Revised 4 January 2012; Accepted 12 January 2012

Academic Editor: Janusz K. Rybakowski

Copyright © 2012 Danielle E. Eagan et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

C-reactive protein (CRP), a systemic marker of inflammation, is a risk factor for late life cognitive impairment and dementia, yet the mechanisms that link elevated CRP to cognitive decline are not fully understood. In this study we examined the relationship between CRP and markers of neuronal integrity and cerebral metabolism in middle-aged adults with intact cognitive function, using proton magnetic resonance spectrocospy. We hypothesized that increased levels of circulating CRP would correlate with changes in brain metabolites indicative of early brain vulnerability. Thirty-six individuals, aged 40 to 60, underwent neuropsychological assessment, a blood draw for CRP quantification, and 1H MRS examining N-acetyl-aspartate, myo-inositol, creatine, choline, and glutamate concentrations in occipito-parietal grey matter. Independent of age, sex and education, serum CRP was significantly related to higher cerebral myo-inositol/creatine ratio (F(4,31)=4.74,  P=0.004), a relationship which remained unchanged after adjustment for cardiovascular risk (F(5,30)=4.356, CRP β = 0.322, P=0.045). Because these biomarkers are detectable in midlife they may serve as useful indicators of brain vulnerability during the preclinical period when mitigating intervention is still possible.