Table 5: Accuracy parameters of different cutoffs of ultrasound parameters for prediction of high white matter hyperintensities score (>20).

Ultrasound parameter Cutoff Sens. Spec. PPV NPV Overall accuracy Cohen’s AUC (95% CI) CCA-Dmean (cm)               0.80  (0.67–0.92) <0.001   ≥0.576 96% 46% 64% 92% 71% 0.423       ≥0.666 65% 89% 85% 72% 77% 0.538       ≥0.705 39% 96% 91% 61% 67% 0.346     CCA-PSV (cm/sec)               0.69 (0.54–0.83) 0.022   ≤34.663 39% 92% 83% 60% 65% 0.308       ≤38.470 62% 69% 67% 65% 65% 0.308       ≤45.315 85% 39% 58% 74% 62% 0.231     ICA-MFV (cm/sec)               0.74 (0.60–0.88) 0.003   ≤19.415 27% 100% 100% 58% 64% 0.269       ≤27.545 77% 77% 77% 77% 77% 0.538       ≤35.990 92% 31% 57% 80% 62% 0.231     MCA-PI               0.82   (0.68–0.95) <0.001   ≥1.063 100% 68% 74% 100% 83% 0.671       ≥1.183 60% 86% 80% 70% 74% 0.469       ≥1.445 25% 91% 71% 57% 60% 0.164

Sens.: sensitivity, spec.: specificity, PPV: positive predictive value, NPV: negative predictive value, AUC: area under the receiver operating characteristic curve, CI: confidence interval.