Neurodegenerative Shielding by Curcumin and Its Derivatives on Brain Lesions Induced by 6-OHDA Model of Parkinson's Disease in Albino Wistar Rats
Figure 2
Photomicrographs of TH immunoreactivity on substantia nigra tissue sections in representative rats of various groups. Rats receiving 6-OHDA intrastriatal injection (B.2) exhibited significant loss of dopaminergic neurons when compared to sham group rats (B.1). Pretreatment with 60 mg/kg curcumin (B.3), BMC (B.4), and BDMC (B.5) for 21 days in 6-OHDA lesioned rats showed less loss of dopaminergic neurons with curcumin group showing maximum protection followed by DMC and BDMC. Scale bar = 100 μm.
