Neurodegenerative Shielding by Curcumin and Its Derivatives on Brain Lesions Induced by 6-OHDA Model of Parkinson's Disease in Albino Wistar Rats
Table 1
Effect of curcumin, DMC, and BDMC on glutathione, glutathione reductase, glutathione peroxidase content, superoxide dismutase, catalase activity, and malondialdehyde (MDA) content in lesioned rats striatum by 6-OHDA.
Groups
Glutathione
Glutathione reductase
Glutathione peroxidase
Superoxide dismutase
Catalase
TBARS (MDA)
(nMol/min/mg of protein)
(nMol/min/mg of protein)
(nMol/min/mg of protein)
(Unit/mg protein)
(nMol/min/mg of protein)
(nMol/min/mg of protein)
S
1.917 ± 0.06
303.3 ± 1.66
515.0 ± 3.32
2.183 ± 0.04
7.717 ± 0.19
12.17 ± 0.70
L
0.95 ± 0.07
125.0 ± 2.18
158.3 ± 0.88
0.7667 ± 0.08
3.583 ± 0.10
33.5 ± 1.23
L+C
1.65 ± 0.07a
246.7 ± 1.66a
343.3 ± 2.45a
1.733 ± 0.06a
6.983 ± 0.18a
19.67 ± 0.71a
L+DMC
1.367 ± 0.08a+
201.7 ± 2.72a,b
500.8 ± 1.83a,b
1.433 ± 0.08a
5.217 ± 0.16a
25.83 ± 0.94a,b+
L+BDMC
1.317 ± 0.04a+,b++
203.3 ± 2.14a,b
360.0 ± 0.66a,c
1.283 ± 0.04a,b+
5.183 ± 0.14a,b+
27.0 ± 1.06a,b
Values are in mean ± SEM (). Levels of significance: a; a+ compared with lesion; b; b+; b++ compared with L+CUR; c; c++ compared with L+DMC.