Research Article

Neurodegenerative Shielding by Curcumin and Its Derivatives on Brain Lesions Induced by 6-OHDA Model of Parkinson's Disease in Albino Wistar Rats

Table 1

Effect of curcumin, DMC, and BDMC on glutathione, glutathione reductase, glutathione peroxidase content, superoxide dismutase, catalase activity, and malondialdehyde (MDA) content in lesioned rats striatum by 6-OHDA.

GroupsGlutathioneGlutathione reductaseGlutathione peroxidaseSuperoxide dismutaseCatalaseTBARS (MDA)
(nMol/min/mg of protein)(nMol/min/mg of protein)(nMol/min/mg of protein)(Unit/mg protein)(nMol/min/mg of protein)(nMol/min/mg of protein)

S1.917 ± 0.06303.3 ± 1.66515.0 ± 3.322.183 ± 0.047.717 ± 0.1912.17 ± 0.70
L0.95 ± 0.07125.0 ± 2.18158.3 ± 0.880.7667 ± 0.083.583 ± 0.1033.5 ± 1.23
L+C1.65 ± 0.07a246.7 ± 1.66a343.3 ± 2.45a1.733 ± 0.06a6.983 ± 0.18a19.67 ± 0.71a
L+DMC1.367 ± 0.08a+201.7 ± 2.72a,b500.8 ± 1.83a,b1.433 ± 0.08a5.217 ± 0.16a25.83 ± 0.94a,b+
L+BDMC1.317 ± 0.04a+,b++203.3 ± 2.14a,b360.0 ± 0.66a,c1.283 ± 0.04a,b+5.183 ± 0.14a,b+27.0 ± 1.06a,b

Values are in mean ± SEM ( ). Levels of significance: a ; a+ compared with lesion; b ; b+ ; b++ compared with L+CUR; c ; c++ compared with L+DMC.