Neurodegenerative Shielding by Curcumin and Its Derivatives on Brain Lesions Induced by 6-OHDA Model of Parkinson's Disease in Albino Wistar Rats

Table 3

Effect of CUR, DMC, and BDMC on striatal dopamine, DOPAC, and HVA levels (mg/g of brain tissue) in rats lesioned by 6-OHDA.

	Dopamine (DA)	3,4-Dihydroxyphenylacetic acid (DOPAC)	Homovanillic acid (HVA)
Sham	13.33 ± 0.64	1.88 ± 0.07	6.37 ± 0.15
Lesion	2.66 ± 0.41	0.45 ± 0.05	1.63 ± 0.17
L+CUR	10.33 ± 0.42^a	1.35 ± 0.07^a	5.23 ± 0.18^a
L+DMC	8.0 ± 0.55^a,b	1.08 ± 0.06^a,b+	4.12 ± 0.14^a,b
L+BDMC	6.66 ± 0.52^a+,b+,c+	1.00 ± 0.08^a+,b+,c+	3.87 ± 0.11^a+,b+,c+

Values are in mean ± SEM (𝑛=6). Levels of significance: ^a𝑃≤0.001; ^a+𝑃≤0.01 compared with lesion; ^b𝑃≤0.001; ^b+𝑃≤0.01 compared with L+CUR; ^c𝑃≤0.001; ^c+𝑃≤0.01 compared with L+DMC.