Review Article

A Systematic Review of Depression and Anxiety in Patients with Atrial Fibrillation: The Mind-Heart Link

Table 1

A summary of studies presented in the Epidemiology depression and anxiety in AF Patients section. Studies in italics only used a depression tool, and articles in bold only assessed anxiety.

StudySubject sizeAim of the studyPsychological testSignificant findings

Epidemiology of depression and anxiety in AF patients

Thrall et al. [19] (2007)101 patients with AF were compared to hypertensive patientsTo report the prevalence of depression and anxiety in patients with AF(i) Trait and State Anxiety
(ii) Beck Depression Inventory
(i) 28% had state anxiety
(ii) 38% had trait anxiety
(iii) 38% had depression

Dabrowski et al. [13] (2010) 150 patients with paroxysmal, persistent, and permanent AF To report quality of life and depression level in patients with various patterns of AF (i) Nottingham Health Profile questionnaire
(ii) Beck Depression Inventory
(i) AF patients had a higher risk of depression
(ii) Patients with paroxysmal and permanent AF had lower self-evaluation of their energy level
(iii) AF limited quality of life, sexual life, and professional and home activity

Ong et al. [20] (2006)93 patients with AF To report the relationship between gender, depression, AF severity(i) Anxiety and Depression (HADS)
(ii) Toronto AF Severity Scale
(i) 11% of patients suffered from depression  
(ii) Women had higher depression scores

Frasure-Smith et al. [14] (2009) 974 patients with AF and CHF To report if depression predicts long-term cardiovascular mortality in patients Beck Depression
Inventory II
(i) 32% had BDI-II scores ≥14 (at least mild-to-moderate symptoms of depression)
(ii) Women, nonwhite, unmarried, and those with lower levels of education had more depression
(iii) Depression symptoms are related to increased cardiovascular mortality

Perret-Guillaume et al. [21] (2010)41 patients with AF were compared to 123 control patientsTo compare HRQoL in AF elderly inpatients with that of age-matched controlled subjects.(i) MOS-SF 36
(ii) The Duke Health Profile
More patients with AF suffered from depression and anxiety

Ariansen et al.
[22] (2011)
27 patients with permanent AF to 75 patients in sinus rhythmTo report if permanent AF patients have more anxiety, depression, and sleep impairment than patients in sinus rhythm(i) Hospital Anxiety and Depression Scale (HADS)
(ii) Pittsburgh Sleep Quality Index (PSQI) score.
(iii) Short Form 36 (SF-36)
Elderly permanent AF patients had similar levels of anxiety, depression, and sleep quality

Suzuki and
Kasanuki [17] (2004)
240 patients with paroxysmal AFTo report the impact of symptoms of anxiety attack and anxiety on HRQOL(i) Trait Anxiety (STAI)(i) Trait anxiety was a predictor of poorer HRQOL
(ii) Anxiety caused fear of attacks and agoraphobic symptoms