Table 3: Baseline characteristics at index date of the patients exposed to antipsychotics, psychiatric nonuser cohort, and general population controls.

CharacteristicExposed to antipsychotics
( = 183,392)
Typical antipsychotics
( = 115,491)
Atypical antipsychotics
( = 67,901)
Psychiatric nonusers
( = 193,920)
General population control
( = 544,726)

Prevalent users67,396 (36.7%)40,258 (34.9%)27,138 (40.0%)0 (0.0%)0 (0.0%)

Female107,226 (58.5%)69,426 (60.1%)37,800 (55.7%)132,458 (68.3%)317,152 (58.2%)
Male76,166 (41.5%)46,065 (39.9%)30,101 (44.3%)61,462 (31.7%)227,574 (41.8%)
Age: mean (sd)60 (22)61 (21)58 (23)52 (22)60 (22)
Age: median (IQR)62 (41–80)64 (44–80)58 (38–81)48 (33–75)61 (41–80)
Age 18–2918,474 (10.1%)9,180 (7.9%)9,294 (13.7%)34,559 (17.8%)55,188 (10.1%)
Age 30–3923,484 (12.8%)13,747 (11.9%)9,737 (14.3%)38,574 (19.9%)70,462 (12.9%)
Age 40–4923,793 (13.0%)14,554 (12.6%)9,239 (13.6%)28,555 (14.7%)71,370 (13.1%)
Age 50–5921,244 (11.6%)14,627 (12.7%)6,617 (9.7%)21,302 (11.0%)63,724 (11.7%)
Age 60–6919,923 (10.9%)14,461 (12.5%)5,462 (8.0%)13,831 (7.1%)59,723 (11.0%)
Age 70–7928,088 (15.3%)18,881 (16.3%)9,207 (13.6%)21,194 (10.9%)84,519 (15.5%)
Age 80+48,386 (26.4%)30,041 (26.0%)18,345 (27.0%)35,905 (18.5%)139,740 (25.7%)
BMI: mean (sd)26 (6)26 (5)26 (6)26 (6)26 (5)
Nonsmoker69,482 (37.9%)44,035 (38.1%)25,447 (37.5%)80,061 (41.3%)249,362 (45.8%)
Ex-smoker29,719 (16.2%)17,638 (15.3%)12,081 (17.8%)39,550 (20.4%)99,240 (18.2%)
Smoker51,938 (28.3%)31,361 (27.2%)20,577 (30.3%)57,004 (29.4%)102,455 (18.8%)
Unknown smoking status32,253 (17.6%)22,457 (19.4%)9,796 (14.4%)17,305 (8.9%)93,669 (17.2%)
Schizophrenia15,475 (8.4%)6,746 (5.8%)8,729 (12.9%)7,779 (4.0%)0 (0.0%)
Bipolar disorder/other mood disorders7,368 (4.0%)3,170 (2.7%)4,198 (6.2%)4,700 (2.4%)0 (0.0%)
Major depression19,981 (10.9%)11,680 (10.1%)8,301 (12.2%)134,105 (69.2%)0 (0.0%)
Dementia25,174 (13.7%)12,669 (11.0%)12,505 (18.4%)47,336 (24.4%)0 (0.0%)
No recorded specific psychiatric disorders115,394 (62.9%)81,226 (70.3%)34,168 (50.3%)0 (0.0%)544,726 (100.0%)
History of alcoholism or drug abuse19,933 (10.9%)11,429 (9.9%)8,504 (12.5%)12,572 (6.5%)13,256 (2.4%)
History of suicide attempts10,777 (5.9%)5,762 (5.0%)5,015 (7.4%)8,841 (4.6%)3,537 (0.6%)
Diabetes mellitus15,276 (8.3%)9,480 (8.2%)5,796 (8.5%)13,639 (7.0%)36,069 (6.6%)
Acute myocardial infarction6,530 (3.6%)4,224 (3.7%)2,306 (3.4%)5,466 (2.8%)19,391 (3.6%)
Prescribing of statins/fibrates in the 3 months before16,203 (8.8%)8,406 (7.3%)7,797 (11.5%)18,124 (9.3%)49,148 (9.0%)
Antiplatelets32,260 (17.6%)18,900 (16.4%)13,360 (19.7%)25,397 (13.1%)72,622 (13.3%)
Antidepressants83,595 (45.6%)49,545 (42.9%)34,050 (50.1%)126,688 (65.3%)34,393 (6.3%)
Anxiolytics27,389 (14.9%)15,637 (13.5%)11,752 (17.3%)12,907 (6.7%)10,185 (1.9%)
Selective serotonin reuptake inhibitors44,428 (24.2%)24,330 (21.1%)20,098 (29.6%)98,373 (50.7%)16,263 (3.0%)
Lithium5,122 (2.8%)2,851 (2.5%)2,271 (3.3%)1,743 (0.9%)115 (<0.1%)
Antiepileptics10,090 (5.5%)5,853 (5.1%)4,237 (6.2%)3,817 (2.0%)5,855 (1.1%)