Table 5: RR of all-cause mortality (excluding suicide) and cardiac mortality in exposed cohort, psychiatric nonuser cohort, and general population controls.

OutcomeExposureNo. of casesIncidence rate per 1000 person-yearsAge, sex-adjusted relative risk (RR) (95% CI)Fully adjusted RR (aRR) (95% CI)

All-cause mortalityGeneral population41,54639.6ReferenceReference
Current use23,84186.12.98 (2.93–3.03)2.72 (2.67–2.77)
Psychiatric nonusers7,76525.3ReferenceReference
Current use23,84186.12.15 (2.10–2.21)1.75 (1.64–1.87)

Cardiac mortalityGeneral population6,53211.9ReferenceReference
Current use2,47817.02.01 (1.92–2.10)1.83 (1.74–1.93)
Psychiatric nonusers1,2896.4ReferenceReference
Current use2,47817.01.62 (1.52–1.74)1.72 (1.42–2.07)

SCD-primary definitionGeneral population460.8ReferenceReference
Current use442.74.45 (2.94–6.73)4.03 (2.63–6.16)
Psychiatric nonusers100.4ReferenceReference
Current use442.75.76 (2.90–11.45)5.76 (2.90–11.45)

SCD-secondary definitionGeneral population2444.0ReferenceReference
Current use17811.03.48 (2.87–4.23)2.89 (2.32–3.60)
Psychiatric nonusers984.1ReferenceReference
Current use17811.02.36 (1.84–3.02)2.15 (1.64–2.81)

SCD-tertiary definitionGeneral population3702.3ReferenceReference
Current use1984.62.47 (2.08–2.94)2.11 (1.73–2.56)
Psychiatric nonusers1191.8ReferenceReference
Current use1984.61.92 (1.53–2.42)1.79 (1.42–2.27)

CHDGeneral population5,9936.6ReferenceReference
Current use1,2695.41.06 (1.00–1.13)*0.94 (0.87–1.00)*
Psychiatric nonusers9823.5ReferenceReference
Current use1,3555.71.08 (1.00–1.18)*1.16 (0.94–1.44)

Ventricular arrhythmiasGeneral population1,9772.2ReferenceReference
Current use6462.71.53 (1.40–1.67)1.49 (1.35–1.64)
Psychiatric nonusers5001.8ReferenceReference
Current use6462.71.14 (1.01–1.28)1.16 (1.02–1.31)

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