Table 8: Relative risk of all-cause mortality (excluding suicide), cardiac mortality, and sudden cardiac death in users of antipsychotics compared to psychiatric nonuser controls stratified by age and daily dose.

OutcomeCharacteristicNo. of casesIncidence rate per 1000 person-yearsFully adjusted RR (aRR) (95% CI)

All-cause mortalityAge < 301214.54.12 (2.72–6.25)
Age 30–643,47322.32.23 (1.85–2.68)
Age 65–796,563127.61.78 (1.57–2.02)
Age ≥ 8013,684322.31.43 (1.31–1.55)

Cardiac mortalityAge < 3070.4—(NC#)
Age 30–642192.82.39 (1.80–3.19)
Age 65–7968227.11.60 (1.40–1.83)
Age ≥ 801,57063.01.55 (1.22–1.98)

SCD-primary definitionAge < 3010.5—(NC#)
Age 30–6481.0—(NC#)
Age 65–79124.5—(NC#)
Age ≥ 80237.4—(NC#)

All-cause mortalityLow daily dose2120897.01.72 (1.62–1.84)
Medium daily dose197852.51.94 (1.80–2.10)
High daily dose65531.91.89 (1.71–2.09)

Cardiac mortalityLow daily dose215720.01.65 (1.36–2.00)
Medium daily dose2519.92.10 (1.68–2.63)
High daily dose705.62.27 (1.68–3.07)

SCD-primary definitionLow daily dose393.35.87 (2.92–11.78)
Medium daily dose41.45.51 (1.69–17.96)
High daily dose10.83.81 (0.47–30.59)

, , , #Not calculable due to small number of cases.