Fatty Acid Desaturase Gene Polymorphisms and Metabolic Measures in Schizophrenia and Bipolar Patients Taking Antipsychotics
Table 4
Demographic and metabolic characteristics based on FADS variants or FADS haplotype.
SNP/haplotypes
FADS1 rs174537
FADS2 rs174570
11
13
14
33
34
Genotype/allele/haplotype genotypes
GG genotype ()
T allele ()
CC genotype ()
T allele ()
GC/GC ()
GC/TC ()
GC/TT ()
TC/TC ()
TC/TT ()
Age (years)
Gender (% female)
37
52
44
48
37
54
50
73
33
Race (% Caucasian/% African American/% other*)
57/34/9
83/8/9
65/27/8
81/8/11
57/35/8
82/10/8
78/11/11
100/0/0
94/6/0
Current smokers (%)
48
47
47
47
48
51
43
27
61
Currently on AAP (%)
78
85
81
84
78
88
85
91
73
BMI (kg/m2)
SBP (mmHg)
DBP (mmHg)
TC (mg/dL)
TG (mg/dL)
HDL (mg/dL)
LDL (mg/dL)
Glucose (mg/dL)
Insulin (µIU/mL)
HOMA-IR
Other includes self-defined race categories of Asian, Hispanic, latino, and others. Significant difference based on a P value cutoff of 0.05 for the FADS1 dominant genetic model. Significant difference based on a P value cutoff of 0.05 for the FADS2 dominant genetic model. Significant difference based on a P value cutoff of 0.05 for haplotype comparisons.
