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Linked References

1. American Heart Association, “Heart and stroke statistics,” 2012, http://www.heart.org/HEARTORG/General/Heart-and-Stroke-Association-Statistics_UCM_319064_SubHomePage.jsp#.
2. Center for Disease Control and Prevention (CDC), “Heart disease facts and statistics,” 2009, http://www.cdc.gov/heartdisease/statistics.htm.
3. F. A. T. C. De Toledo, L. K. Ferreira, M. Wajngarten, and G. F. Busatto, “Cardiac disorders as risk factors for Alzheimer's disease,” Journal of Alzheimer's Disease, vol. 20, no. 3, pp. 749–763, 2010. View at Publisher · View at Google Scholar · View at Scopus
4. R. A. Cohen, A. Poppas, D. E. Forman et al., “Vascular and cognitive functions associated with cardiovascular disease in the elderly,” Journal of Clinical and Experimental Neuropsychology, vol. 31, no. 1, pp. 96–110, 2009. View at Publisher · View at Google Scholar · View at Scopus
5. R. L. C. Vogels, J. M. Oosterman, B. Van Harten et al., “Profile of cognitive impairment in chronic heart failure,” Journal of the American Geriatrics Society, vol. 55, no. 11, pp. 1764–1770, 2007. View at Publisher · View at Google Scholar · View at Scopus
6. K. Rockwood, C. Wentzel, V. Hachinski, D. B. Hogan, C. MacKnight, and I. McDowell, “Prevalence and outcomes of vascular cognitive impairment,” Neurology, vol. 54, no. 2, pp. 447–451, 2000. View at Scopus
7. J. T. O'Brien, “Vascular cognitive impairment,” American Journal of Geriatric Psychiatry, vol. 14, no. 9, pp. 724–733, 2006. View at Publisher · View at Google Scholar
8. P. S. Sachdev, H. Brodaty, M. J. Valenzuela et al., “The neuropsychological profile of vascular cognitive impairment in stroke and TIA patients,” Neurology, vol. 62, no. 6, pp. 912–919, 2004. View at Scopus
9. K. D. Garrett, J. N. Browndyke, W. Whelihan et al., “The neuropsychological profile of vascular cognitive impairment—no dementia: comparisons to patients at risk for cerebrovascular disease and vascular dementia,” Archives of Clinical Neuropsychology, vol. 19, no. 6, pp. 745–757, 2004. View at Publisher · View at Google Scholar · View at Scopus
10. Mayo Clinic, “Heart disease in women: understand symptoms and risk factors,” 2009, http://www.mayoclinic.com/health/heart-disease/HB00040.
11. I. S. Khawaja, J. J. Westermeyer, P. Gajwani, and R. E. Feinstein, “Depression and coronary artery disease: the association, mechanisms and therapeutic implications,” Psychiatry, vol. 6, no. 1, pp. 38–51, 2009. View at Scopus
12. J. Barth, M. Schumacher, and C. Herrmann-Lingen, “Depression as a risk factor for mortality in patients with coronary heart disease: a meta-analysis,” Psychosomatic Medicine, vol. 66, no. 6, pp. 802–813, 2004. View at Publisher · View at Google Scholar · View at Scopus
13. A. H. Glassman and P. A. Shapiro, “Depression and the course of coronary artery disease,” American Journal of Psychiatry, vol. 155, no. 1, pp. 4–11, 1998. View at Scopus
14. R. Ylikoski, A. Ylikoski, R. Raininko et al., “Cardiovascular diseases, health status, brain imaging findings and neuropsychological functioning in neurologically healthy elderly individuals,” Archives of Gerontology and Geriatrics, vol. 30, no. 2, pp. 115–130, 2000. View at Publisher · View at Google Scholar · View at Scopus
15. L. L. Herrmann, M. Le Masurier, and K. P. Ebmeier, “White matter hyperintensities in late life depression: a systematic review,” Journal of Neurology, Neurosurgery and Psychiatry, vol. 79, no. 6, pp. 619–624, 2008. View at Publisher · View at Google Scholar · View at Scopus
16. R. D. Nebes, C. F. Reynolds, F. Boada et al., “Longitudinal increase in the volume of white matter hyperintensities in late-onset depression,” International Journal of Geriatric Psychiatry, vol. 17, no. 6, pp. 526–530, 2002. View at Publisher · View at Google Scholar · View at Scopus
17. M. A. Ikram, H. J. Luijendijk, M. W. Vernooij et al., “Vascular brain disease and depression in the elderly,” Epidemiology, vol. 21, no. 1, pp. 78–81, 2010. View at Publisher · View at Google Scholar · View at Scopus
18. S. A. Ligthart, E. Richard, N. L. Fransen, et al., “Association of vascular factors with apathy in community-dwelling elderly individuals,” Archives of General Psychiatry, vol. 69, no. 6, pp. 636–642, 2012.
19. R. C. van der Mast, D. J. Vinkers, M. L. Stek et al., “Vascular disease and apathy in old age. The Leiden 85-plus study,” International Journal of Geriatric Psychiatry, vol. 23, no. 3, pp. 266–271, 2008. View at Publisher · View at Google Scholar · View at Scopus
20. R. S. Marin, “Differential diagnosis of apathy and related disorders of diminished motivation,” Psychiatric Annals, vol. 27, no. 1, pp. 30–33, 1997. View at Scopus
21. M. L. Levy, J. L. Cummings, L. A. Fairbanks et al., “Apathy is not depression,” The Journal of Neuropsychiatry and Clinical Neurosciences, vol. 10, no. 3, pp. 314–319, 1998.
22. R. S. Marin, “Apathy: a neuropsychiatric syndrome,” Journal of Neuropsychiatry and Clinical Neurosciences, vol. 3, no. 3, pp. 243–254, 1991. View at Scopus
23. S. E. Starkstein and A. F. G. Leentjens, “The nosological position of apathy in clinical practice,” Journal of Neurology, Neurosurgery and Psychiatry, vol. 79, no. 10, pp. 1088–1092, 2008. View at Publisher · View at Google Scholar · View at Scopus
24. R. Van Reekum, D. T. Stuss, and L. Ostrander, “Apathy: why care?” Journal of Neuropsychiatry and Clinical Neurosciences, vol. 17, no. 1, pp. 7–19, 2005. View at Publisher · View at Google Scholar · View at Scopus
25. H. Brodaty, A. Altendorf, A. Withall, and P. Sachdev, “Do people become more apathetic as they grow older? A longitudinal study in healthy individuals,” International Psychogeriatrics, vol. 22, no. 3, pp. 426–436, 2010. View at Publisher · View at Google Scholar · View at Scopus
26. S. A. Factor and W. J. Weiner, Eds., Parkinson's Disease: Diagnosis and Clinical Management, Demos Medical, New York, NY, USA, 2002.
27. S. E. Starkstein, J. P. Fedoroff, T. R. Price, R. Leiguarda, and R. G. Robinson, “Apathy following cerebrovascular lesions,” Stroke, vol. 24, no. 11, pp. 1625–1630, 1993. View at Scopus
28. R. H. Paul, A. M. Brickman, B. Navia et al., “Apathy is associated with volume of the nucleus accumbens in patients infected with HIV,” Journal of Neuropsychiatry and Clinical Neurosciences, vol. 17, no. 2, pp. 167–171, 2005. View at Publisher · View at Google Scholar · View at Scopus
29. D. Tate, R. H. Paul, T. P. Flanigan et al., “The impact of apathy and depression on quality of life in patients infected with HIV,” AIDS Patient Care and STDs, vol. 17, no. 3, pp. 115–120, 2003. View at Publisher · View at Google Scholar · View at Scopus
30. S. E. Starkstein, G. Petracca, E. Chemerinski, and J. Kremer, “Syndromic validity of apathy in Alzheimer's disease,” American Journal of Psychiatry, vol. 158, no. 6, pp. 872–877, 2001. View at Publisher · View at Google Scholar · View at Scopus
31. G. C. Pluck and R. G. Brown, “Apathy in Parkinson's disease,” Journal of Neurology Neurosurgery and Psychiatry, vol. 73, no. 6, pp. 636–642, 2002. View at Publisher · View at Google Scholar · View at Scopus
32. S. E. Starkstein, H. S. Mayberg, T. J. Preziosi, P. Andrezejewski, R. Leiguarda, and R. G. Robinson, “Reliability, validity, and clinical correlates of apathy in Parkinson's disease,” Journal of Neuropsychiatry and Clinical Neurosciences, vol. 4, no. 2, pp. 134–139, 1992. View at Scopus
33. A. H. Craig, J. L. Cummings, L. Fairbanks et al., “Cerebral blood flow correlates of apathy in Alzheimer disease,” Archives of Neurology, vol. 53, no. 11, pp. 1116–1120, 1996. View at Scopus
34. H. Brodaty, M. Heffernan, B. Draper, et al., “Neuropsychiatric symptoms in older people with and without cognitive impairment,” Journal of Alzheimer's Disease, vol. 31, pp. 411–420, 2012.
35. L. B. Zahodne and G. Tremont, “Unique effects of apathy and depression signs on cognition and function in amnestic mild cognitive impairment,” International Journal of Geriatric Psychiatry, vol. 28, no. 1, pp. 50–56, 2012. View at Publisher · View at Google Scholar
36. R. L. Drijgers, F. R. Verhey, A. F. Leentjens, S. Kohler, and P. Aalten, “Neuropsychological correlates of apathy in mild cognitive impairment and Alzheimer's disease: the role of executive function,” Psychogeriatrics, vol. 23, pp. 1327–1333, 2011.
37. S. Paradiso, E. Chemerinski, K. M. Yazici, A. Tartaro, and R. G. Robinson, “Frontal lobe syndrome reassessed: comparison of patients with lateral or medial frontal brain damage,” Journal of Neurology Neurosurgery and Psychiatry, vol. 67, no. 5, pp. 664–667, 1999. View at Scopus
38. R. A. Cohen, “Introduction,” in Neuropsychology and Cardiovascular Disease, R. A. Cohen and J. Gunstad, Eds., pp. 3–18, Oxford University Press, New York, NY, USA, 2010.
39. S. E. Starkstein, R. Mizrahi, A. A. Capizzano, L. Acion, S. Brockman, and B. D. Power, “Neuroimaging correlates of apathy and depression in Alzheimer's disease,” Journal of Neuropsychiatry and Clinical Neurosciences, vol. 21, no. 3, pp. 259–265, 2009. View at Publisher · View at Google Scholar · View at Scopus
40. R. Paul, T. P. Flanigan, K. Tashima et al., “Apathy correlates with cognitive function but not CD4 status in patients with human immunodeficiency virus,” Journal of Neuropsychiatry and Clinical Neurosciences, vol. 17, no. 1, pp. 114–118, 2005. View at Publisher · View at Google Scholar · View at Scopus
41. L. C. Butterfield, C. R. Cimino, L. E. Oelke, R. A. Hauser, and J. Sanchez-Ramos, “The independent Influence of apathy and depression on cognitive functioning in Parkinson's disease,” Neuropsychology, vol. 24, no. 6, pp. 721–730, 2010. View at Publisher · View at Google Scholar · View at Scopus
42. American Psychiatric Association, Diagnostic and Statistical Manual of Mental Disorders, American Psychiatric Association, Washington, DC, 4th ed edition, 2000.
43. R. S. Marin, R. C. Biedrzycki, and S. Firinciogullari, “Reliability and validity of the apathy evaluation scale,” Psychiatry Research, vol. 38, no. 2, pp. 143–162, 1991. View at Publisher · View at Google Scholar · View at Scopus
44. R. C. Arnau, M. W. Meagher, M. P. Norris, and R. Bramson, “Psychometric evaluation of the Beck Depression Inventory-II with primary care medical patients,” Health Psychology, vol. 20, no. 2, pp. 112–119, 2001. View at Publisher · View at Google Scholar · View at Scopus
45. A. T. Beck, R. A. Steer, and G. K. Brown, Beck Depression Inventory, The Psychological Corporation, San Antonio, Tex, USA, 2nd edition, 1996.
46. E. L. Teng and H. C. Chui, “The Modified Mini-Mental State (3MS) examination,” Journal of Clinical Psychiatry, vol. 48, no. 8, pp. 314–318, 1987. View at Scopus
47. S. S. Dikmen, R. K. Heaton, I. Grant, and N. R. Temkin, “Test-retest reliability and practice effects of expanded Halstead-Reitan Neuropsychological Test Battery,” Journal of the International Neuropsychological Society, vol. 5, no. 4, pp. 346–356, 1999. View at Publisher · View at Google Scholar · View at Scopus
48. R. De Raedt and I. Ponjaert-Kristoffersen, “Short cognitive/neuropsychological test battery for firsttier fitness-to-drive assessment of older adults,” Clinical Neuropsychologist, vol. 15, no. 3, pp. 329–336, 2001. View at Publisher · View at Google Scholar · View at Scopus
49. A. J. Levine, E. N. Miller, J. T. Becker, O. A. Selnes, and B. A. Cohen, “Normative data for determining significance of test-retest differences on eight common neuropsychological instruments,” Clinical Neuropsychologist, vol. 18, no. 3, pp. 373–384, 2004. View at Publisher · View at Google Scholar · View at Scopus
50. R. M. Ruff and C. C. Allen, Ruff 2 & 7 Selective Attention Test Professiona Manual, Psychological Assessment Resources, Odessa, Fla, USA, 1996.
51. American College of Sports Medicine, ACSM'S Health Related FitneSS Assessment Manual, Lippincott, Williams, & Wilkins, New York, NY, USA, 2005.
52. A. T. Lane-Brown and R. L. Tate, “Measuring apathy after traumatic brain injury: psychometric properties of the Apathy Evaluation Scale and the Frontal Systems Behavior Scale,” Brain Injury, vol. 23, no. 13-14, pp. 999–1007, 2009. View at Publisher · View at Google Scholar · View at Scopus
53. M. A. Woo, P. M. Macey, G. C. Fonarow, M. A. Hamilton, and R. M. Harper, “Regional brain gray matter loss in heart failure,” Journal of Applied Physiology, vol. 95, no. 2, pp. 677–684, 2003. View at Scopus
54. J. Hill and A. Timmis, “ABC of clinical electrocardiography: exercise tolerance testing,” British Medical Journal, vol. 324, no. 7345, pp. 1084–1087, 2002. View at Scopus
55. E. P. Havranek, M. G. Ware, and B. D. Lowes, “Prevalence of depression in congestive heart failure,” American Journal of Cardiology, vol. 84, no. 3, pp. 348–350, 1999. View at Publisher · View at Google Scholar · View at Scopus
56. M. Glenn, “The apahty evaluation scale,” The Center for Outcome Measurement in Brain Injury, 2005, http://www.tbims.org/combi/aes/index.html.
57. A. T. F. Beekman, B. W. J. H. Penninx, D. J. H. Deeg et al., “Depression in survivors of stroke: a community-based study of prevalence, risk factors and consequences,” Social Psychiatry and Psychiatric Epidemiology, vol. 33, no. 10, pp. 463–470, 1998. View at Publisher · View at Google Scholar · View at Scopus
58. P. W. Burvill, G. A. Johnson, K. D. Jamrozik, C. S. Anderson, E. G. Stewart-Wynne, and T. M. H. Chakera, “Prevalence of depression after stroke: the Perth community stroke study,” British Journal of Psychiatry, vol. 166, pp. 320–327, 1995. View at Scopus
59. A. T. Beck, R. A. Steer, and M. G. Garbin, “Psychometric properties of the Beck Depression Inventory: twenty-five years of evaluation,” Clinical Psychology Review, vol. 8, no. 1, pp. 77–100, 1988. View at Scopus
60. M. B. Gonzalez, T. B. Snyderman, J. T. Colket et al., “Depression in patients with coronary artery disease,” Depression, vol. 4, pp. 57–62, 1996.
61. S. A. Castellon, C. H. Hinkin, S. Wood, and K. T. Yarema, “Apathy, depression, and cognitive performance in HIV-1 infection,” Journal of Neuropsychiatry and Clinical Neurosciences, vol. 10, no. 3, pp. 320–329, 1998. View at Scopus
62. R. Paul, T. P. Flanigan, K. Tashima et al., “Apathy correlates with cognitive function but not CD4 status in patients with human immunodeficiency virus,” Journal of Neuropsychiatry and Clinical Neurosciences, vol. 17, no. 1, pp. 114–118, 2005. View at Publisher · View at Google Scholar · View at Scopus
63. G. A. Heckman, C. J. Patterson, C. Demers, J. St Onge, I. D. Turpie, and R. S. McKelvie, “Heart failure and cognitive impairment: challenges and opportunities,” Clinical Interventions in Aging, vol. 2, no. 2, pp. 209–218, 2007. View at Scopus
64. S. J. Pressler, U. Subramanian, D. Kareken et al., “Cognitive deficits in chronic heart failure,” Nursing Research, vol. 59, no. 2, pp. 127–139, 2010. View at Publisher · View at Google Scholar · View at Scopus
65. R. L. C. Vogels, W. M. van der Flier, B. van Harten et al., “Brain magnetic resonance imaging abnormalities in patients with heart failure,” European Journal of Heart Failure, vol. 9, no. 10, pp. 1003–1009, 2007. View at Publisher · View at Google Scholar · View at Scopus
66. K. F. Hoth, A. Poppas, D. J. Moser, R. H. Paul, and R. A. Cohen, “Cardiac dysfunction and cognition in older adults with heart failure,” Cognitive and Behavioral Neurology, vol. 21, no. 2, pp. 65–72, 2008. View at Publisher · View at Google Scholar · View at Scopus
67. S. Garcia, M. B. Spitznagel, R. Cohen et al., “Depression is associated with cognitive dysfunction in older adults with heart failure,” Cardiovasc Psychiatry Neurol, vol. 2011, Article ID 368324, 6 pages, 2011. View at Publisher · View at Google Scholar