Risk Factors Associated with Cognitive Decline after Cardiac Surgery: A Systematic Review

Table 2

Studies investigating POCD associated with intraoperative blood pressure variation.

Study	Study; design	Number of; patients	Type of intervention	Time of assessment	Outcome
Gold et al., 1995 [8]	RCT	248	High (80–100 mmHg) versus low (50–60 mmHg) BP	6 months	Decline with lower BP
Siepe et al., 2011 [9]	RCT	92	High (80–90 mmHg) versus low (60–70 mmHg) BP	2 days	Decline with lower BP
Gottesman et al., 2007 [51]	Obsv.	15	Low MAP (50–70 mmHg)	3–5 days and 1 month	Decline with lower BP
Newman et al., 1995 [52]	Obsv.	237	Low MAP (50–60 mmHg)	Discharge	Decline with lower BP
Charlson et al., 2007 [10]	RCT	412	High MAP (57–90 mmHg) versus custom (capped at 90 mmHg)	6 months	No difference in outcome

Obsv.: observational.