A Validated High-Performance Liquid Chromatography-Tandem Mass Spectrometric (Lc-Ms/Ms) Method for Simultaneous Determination of R(+)-Ketorolac and S(−)-Ketorolac in Human Plasma and Its Application to a Bioequivalence Study

Table 2

Optimized ion source and compound parameters.

Parameter	R(+)-Ketorolac	S(−)-Ketorolac	S(+)-Etodolac
Declustering potential	41.00 V	41.00 V	32.00 V
Entrance potential	10.00 V	10.00 V	10.00 V
Collision energy	25.00 V	25.00 V	19.00 V
Clustering cell exit potential	2.00 V	2.00 V	2.00 V
Temperature	550∘C	550∘C	550∘C
Collision associated dissociation	5	5	5
Curtain gas	25	25	25
Ion spray voltage	1500	1500	1500