Stability-Indicating HPTLC Method for Determination of Duloxetine Hydrochloride in Bulk Drug and Tablet Formulation

Table 4

Stress degradation of duloxetine hydrochloride.

Stress conditions*	Degradation products; (𝑅𝑓 value)	Recovery; (%)
0.5 M HCl RT (4 h)	2, (0.12, 0.21)	83.13%
2.0 N NaOH RT (8 h)	2, (0.19, 0.28)	92.28%
30% H2O2 RT (8 h)	2,(0.19, 0.31)	91.11%
Heat (70°C) (5 h)	1, (0.24)	94.45%

*(𝑛=3), RT (room temperature), h (hours).