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Chromatography Research International
Volume 2011 (2011), Article ID 860168, 8 pages
http://dx.doi.org/10.4061/2011/860168
Research Article

LC and UV Methods for Lamotrigine Determination in Pharmaceutical Formulation

Faculdade de Farmácia, Universidade Federal do Rio Grande do Sul, Avendia Ipiranga, 2752/402, 90610-000 Porto Alegre, RS, Brazil

Received 12 July 2010; Revised 3 December 2010; Accepted 14 December 2010

Academic Editor: Toyohide Takeuchi

Copyright © 2011 Magda T. Martins et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. F. D. Fuchs and L. Wannmacher, Farmacologia Clínica, Guanabara Koogan, Rio de Janeiro, Brazil, 2004.
  2. J. O. McNamara, Goodman & Gilmans: As Bases Farmacológicas da Terapêutica, McGraw Hill, Rio de Janeiro, Brazil, 2003.
  3. E. Ben-Menachem, “New antiepileptic drugs and non-pharmacological treatments,” Current Opinion in Neurology, vol. 13, no. 2, pp. 165–170, 2000.
  4. C. L. Cheng, C. H. Chou, and O. Y. P. Hu, “Determination of lamotrigine in small volumes of plasma by high-performance liquid chromatography,” Journal of Chromatography B, vol. 817, no. 2, pp. 199–206, 2005. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  5. D. Croci, A. Salmaggi, U. De Grazia, and G. Bernardi, “New high-performance liquid chromatographic method for plasma/serum analysis of lamotrigine,” Therapeutic Drug Monitoring, vol. 23, no. 6, pp. 665–668, 2001. View at Publisher · View at Google Scholar · View at Scopus
  6. M. M. Castel-Branco, A. M. Almeida, A. C. Falcão, T. A. Macedo, M. M. Caramona, and F. G. Lopez, “Lamotrigine analysis in blood and brain by high-performance liquid chromatography,” Journal of Chromatography B, vol. 755, no. 1-2, pp. 119–127, 2001. View at Publisher · View at Google Scholar · View at Scopus
  7. M. Torra, M. Rodamilans, S. Arroyo, and J. Corbella, “Optimized procedure for lamotrigine analysis in serum by high-performance liquid chromatography without interferences from other frequently coadministered anticonvulsants,” Therapeutic Drug Monitoring, vol. 22, no. 5, pp. 621–625, 2000. View at Publisher · View at Google Scholar · View at Scopus
  8. N. R. Barbosa and A. F. Midio, “Validated high-performance liquid chromatographic method for the determination of lamotrigine in human plasma,” Journal of Chromatography B, vol. 741, no. 2, pp. 289–293, 2000. View at Publisher · View at Google Scholar · View at Scopus
  9. Y. Bottiger, J. O. Svensson, and L. Stahle, “Lamotrigine drug interactions in a TDM material,” Therapeutic Drug Monitoring, vol. 21, no. 2, pp. 171–174, 1999. View at Publisher · View at Google Scholar · View at Scopus
  10. E. Vidal, C. Pascual, and L. Pou, “Determination of lamotrigine in human serum by liquid chromatography,” Journal of Chromatography B, vol. 736, no. 1-2, pp. 295–298, 1999. View at Publisher · View at Google Scholar · View at Scopus
  11. P. Angelis-Stoforidis, D. J. Morgan, T. J. O'Brien, and F. J. E. Vajda, “Determination of lamotrigine in human plasma by high-performance liquid chromatography,” Journal of Chromatography B, vol. 727, no. 1-2, pp. 113–118, 1999. View at Publisher · View at Google Scholar · View at Scopus
  12. K. M. Matar, P. J. Nicholls, S. A. Bawazir, M. I. Al-Hassan, and A. Tekle, “A rapid liquid chromatographic method for the determination of lamotrigine in plasma,” Journal of Pharmaceutical and Biomedical Analysis, vol. 17, no. 3, pp. 525–531, 1998. View at Publisher · View at Google Scholar · View at Scopus
  13. B. C. Sallustio and R. G. Morris, “High-performance liquid chromatography quantitation of plasma lamotrigine concentrations: application measuring trough concentrations in patients with epilepsy,” Therapeutic Drug Monitoring, vol. 19, no. 6, pp. 688–693, 1997. View at Publisher · View at Google Scholar · View at Scopus
  14. M. Cociglio, R. Alric, and O. Bouvier, “Performance analysis of a reversed-phase liquid chromatographic assay of lamotrigine in plasma using solvent-demixing extraction,” Journal of Chromatography, vol. 572, no. 1-2, pp. 269–276, 1991. View at Publisher · View at Google Scholar · View at Scopus
  15. S. M. Addolorata, B. Francesca, C. Matteo, A. Mario, and M. A. Raggi, “Rapid HPLC analysis of the antiepileptic lamotrigine and its metabolites in human plasma,” Journal of Separation Science, vol. 30, no. 14, pp. 2249–2255, 2007. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  16. S. Bompadre, A. Tagliabracci, M. Battino, and R. Giorgetti, “Determination of lamotrigine in whole blood with on line solid phase extraction,” Journal of Chromatography B, vol. 863, no. 1, pp. 177–180, 2008. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  17. E. Griner-Sosanko, D. R. Lower, M. A. Virji, and M. D. Krasowski, “Simultaneous determination of lamotrigine, zonisamide and carbamazepine in human plasma by high-performance liquid chromatography,” Biomedical Chromatography, vol. 21, no. 3, pp. 225–228, 2007. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  18. J. Emami, N. Ghassami, and F. Ahmadi, “Development and validation of a new HPLC method for determination of lamotrigine and related compounds in tablet formulations,” Journal of Pharmaceutical and Biomedical Analysis, vol. 40, no. 4, pp. 999–1005, 2006. View at Publisher · View at Google Scholar · View at PubMed
  19. N. F. Youssef and E. A. Taha, “Development and validation of spectrophotometric, TLC and HPLC methods for the determination of lamotrigine in presence of its impurity,” Chemical and Pharmaceutical Bulletin, vol. 55, no. 4, pp. 541–545, 2007. View at Publisher · View at Google Scholar · View at Scopus
  20. S. Pollisetty, M. Khagga, R. R. Buchi, and S. S. V. Koduvi, “Development of a validated stability indicating LC method for lamotrigine,” Chromatographia, vol. 70, no. 1-2, pp. 271–276, 2009. View at Publisher · View at Google Scholar · View at Scopus
  21. International Conference on Harmonization (ICH), “Validation of Analytical Procedures: Validation of Analytical Procedures: methodology Q2B,” Consensus Guideline, November 1996.
  22. British Pharmacopoeia 2005, Not Avail, London, UK, 2005.
  23. United States Pharmacopeia, USP Convention, Rockville, Md, USA, 2008.
  24. S. Klick, P. G. Muijselaar, J. Waterval et al., “Toward a generic approach for: Stress testing of drug substances and drug products,” Pharmaceutical Technology, vol. 29, no. 2, pp. 48–66, 2005. View at Scopus
  25. Proceedings of the International Conference on Harmonization (ICH), Stability Testing of New Drug Substance and Products: Methodology Q1A(R2), 2003.
  26. Proceedings of the International Conference on Harmonization (ICH), Harmonized Tripartite Guideline, Validation of Analytical Procedures: Text and Methodology Q2 (R1), 2005.
  27. M. Bakshi and S. Singh, “Development of validated stability-indicating assay methods—critical review,” Journal of Pharmaceutical and Biomedical Analysis, vol. 28, no. 6, pp. 1011–1040, 2002. View at Publisher · View at Google Scholar · View at Scopus
  28. R. L. Snyder, J. Kirkland, and L. Glajch, Pratical HPLC Method Development, Jonh Wiley & Sons, Hoboken, NY, USA, 1997.
  29. G. A. Shabir, “Validation of high-performance liquid chromatography methods for pharmaceutical analysis: understanding the differences and similarities between validation requirements of the US Food and Drug Administration, the US Pharmacopeia and the International Conference on Harmonization,” Journal of Chromatography A, vol. 987, no. 1-2, pp. 57–66, 2003. View at Publisher · View at Google Scholar · View at Scopus
  30. FDA, Center for Drug Evaluation and Research. Reviewer Guidance: Validation of Chromatographic Methods, Rockville, Md, USA, 1994.
  31. H. G. Brittain, “Validação de métodos não-cromatográficos,” Pharmaceutical Technology, vol. 2, no. 3, p. 4, 1998.