Stability-Indicating Gradient RP-LC Method for the Determination of Process and Degradation Impurities in Bosentan Monohydrate: An Endothelin Receptor Antagonist

<table class="table-group" width="800px"><tr class="fig-image" id="a"><td><img alt="929876.fig.004a" src="https://static.hindawi.com/articles/cri/volume-2011/929876/figures/929876.fig.004a.jpg"/></td></tr><tr class="fig-caption"><td align="center"><table><tr><td><b>(a) </b>Acid treated test sample</td></tr></table></td></tr><tr class="fig-image" id="b"><td><img alt="929876.fig.004b" src="https://static.hindawi.com/articles/cri/volume-2011/929876/figures/929876.fig.004b.jpg"/></td></tr><tr class="fig-caption"><td align="center"><table><tr><td><b>(b) </b>Alkali treated test sample</td></tr></table></td></tr></table>

<table>Typical RP-LC chromatograms of forced degradation study: (a) acid treated test sample and (b) base treated test sample.</table>

Chromatography Research International

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Figure 4

Figure 4: Stability-Indicating Gradient RP-LC Method for the Determination of Process and Degradation Impurities in Bosentan Monohydrate: An Endothelin Receptor Antagonist 

Figure 4 | Stability-Indicating Gradient RP-LC Method for the Determination of Process and Degradation Impurities in Bosentan Monohydrate: An Endothelin Receptor Antagonist 