Chromatography Research International

Research Article

Pharmacokinetics of Single-Dose and Multi-Dose of Lovastatin/Niacin ER Tablet in Healthy Volunteers

Table 4

The pharmacokinetic variables of NA, NAM, and NUA in volunteers after single- and multi-dose administration of the treatment A (niacin ER tablet, 500 mg) or the treatment C (lovastatin/niacin ER tablet, 20 mg/500 mg) (mean ± SD).


	Treatment		NA			NAM			NUA
	Treatment		(h)	(μg/mL)	AUC_0–24 (μg·h/mL)	(h)	(μg/mL)	AUC_0–24 (μg·h/mL)	(h)	(μg/mL)	AUC_0–24 (μg·h/mL)	(h)

C	Single	Mean	1.1	0.079	0.104	7.2	0.148	2.09	1.5	0.404	0.94	1.9
	Single	±s	0.8	0.061	0.067	4.3	0.061	0.79	0.4	0.114	0.32	0.6
	Multi	Mean	2.6	0.097	0.221	10.2	0.448	5.81	2.4	0.375	1.19	1.4
	Multi	±s	1.1	0.043	0.055	0.6	0.104	1.29	1.1	0.127	0.38	0.2

A	Single	Mean	2.1	0.0392	0.0761	5.1	0.176	1.82	2.8	0.232	0.743	1.8
	Single	±s	1.6	0.0253	0.0385	0.6	0.068	1.10	1.4	0.062	0.217	0.4
	Multi	Mean	3.3	0.155	0.221	11.6	0.375	5.31	3.15	0.340	0.781	1.3
	Multi	±s	1.3	0.121	0.157	3.1	0.050	1.01	1.1	1.18	0.205	0.07

	Single	C/A		1.06	1.14		0.96	1.08		1.12	1.09
	Single	90%		0.94, 1.21	0.98, 1.29		0.80, 1.25	0.92, 1.24		0.96, 1.30	0.94, 1.24

	Multi	C/A		1.03	1.06		1.09	1.10		1.11	1.06
	Multi	90%		0.88, 1.22	0.96, 1.16		0.94, 1.26	0.99, 1.20		0.81, 1.21	0.93, 1.19