Pharmacokinetics of Single-Dose and Multi-Dose of Lovastatin/Niacin ER Tablet in Healthy Volunteers

Table 6

The pharmacokinetic variables of lovastatin in volunteers after single-dose administration of lovastatin/niacin ER (20 mg/500 mg) and lovastatin (20 mg) (mean ± SD).

Variable	Lovastatin/niacin ER (treatment C)		lovastatin (treatment B)
	Single-dose	Multi-dose	Single-dose	Multi-dose
𝑇max (h)	1.3 ± 0.5	1.3 ± 0.6	1.4 ± 0.2	1.5 ± 0.3
𝐶max (ng/mL)	10.94 ± 3.51	10.25 ± 3.12	9.54±4.47	8.45 ± 2.77
AUC0–24 (ng·h/mL)	26.97 ± 6.2	29.85 ± 10.25	27.78 ± 10.33	26.86 ± 8.53
𝑡1/2 (h)	3.9 ± 0.8	4.6 ± 1.4	3.8 ± 1.5	5.1 ± 0.5
	Single (C/B, 90%)		Multi (C/B, 90%)
𝐶max	1.12, (1.00, 1.24)		1.14, (1.04, 1.24)
AUC0–24	1.13, (1.01, −1.24)		1.15, (1.04, 1.25)