Development and Validation of a Stability Indicating LC Method for the Assay and Related Substances Determination of a Proteasome Inhibitor Bortezomib

Table 1

Factors and level studied for robustness testing.

Factors	Level
	−1	0	+1
(A)  Flow rate (mL/min)	0.8	1.0	1.2
(B)  Acetonitrile (%)	28.0	28.5	29.0
(C)  Methanol (%)	79.0	80.0	81.0