Development and Validation of a Stability Indicating LC Method for the Assay and Related Substances Determination of a Proteasome Inhibitor Bortezomib

Table 7

Regression coefficients and the associated probability values (𝑃-value) for each response.

Term	Resolution-1		Resolution-2		Bortezomib
	Coeff.	𝑃-value	Coeff.	𝑃-value	Coeff.	𝑃-value
Constant	3.43	0	2.54	0	99.92	0
Factor A	−0.150	0.1549	−0.100	0.0545	0.000	1.0000
Factor B	−0.100	0.3151	0.000	1.0000	−0.100	0.3763
Factor C	−0.100	0.3151	0.050	0.2668	−0.050	0.6480
A × B	−0.100	0.4039	0.100	0.0968	−0.075	0.5781
A × C	−0.050	0.6677	0.000	1.0000	−0.075	0.5781
B × C	−0.100	0.4039	−0.050	0.3544	0.075	0.5781
A^2	−0.344	0.0074	−0.032	0.4038	−0.413	0.0062
B^2	−0.194	0.0575	−0.032	0.4038	−0.113	0.2703
C^2	0.005	0.9477	−0.182	0.0036	−0.263	0.0343