A Validated Stability Indicating RP-HPLC Method Development and Validation for Simultaneous Estimation of Aliskiren Hemifumarate and Amlodipine Besylate in Pharmaceutical Dosage Form

Table 7

Forced degradation studies of aliskiren and amlodipine.

Stress condition	Aliskiren			Amlodipine
	% degradation	Purity of angle	Purity of threshold	% degradation	Purity of angle	Purity of threshold
Acid degradation	9.7%	0.436	0.628	9.1%	0.568	1.168
Alkali degradation	9.12%	0.513	0.714	6.15%	4.056	6.792
Oxidative degradation	8.22%	0.429	0.618	7.28	3.096	4.610
Photolytic degradation	1.31%	0.305	0.513	2.03%	1.051	1.307
Thermal degradation	8.05%	0.420	0.816	4.68%	1.099	1.936