“First in Man”: Case Report of Selective C-Reactive Protein Apheresis in a Patient with Acute ST Segment Elevation Myocardial Infarction

Figure 2

CRP levels and cardiac enzyme progress. CRP levels (a) were normal (normal value 0–5 mg/l) at admission and increased as a result of myocardial necrosis/acute phase reaction as expected. CRP apheresis 1 and 2 (blue columns) 34 h and 58 h after the onset of symptoms (27 h and 51 h after first laboratory results, i.e., zero point in the coordinate system) decreased from 28.77 mg/l to 12.58 mg/l during the first apheresis session and from 24.17 mg/l to 11.55 mg/l during the second session, respectively. CRP apheresis thus efficiently counteracted acute phase CRP elevation. Elevated CK/CK-MB and troponin levels at admission (b) documented acute STEMI. CK levels peaked approximately 14 h after the onset of symptoms and decreased afterwards. -axis left: pg/ml for hsTroponin T; -axis right: U/l for CK and CK-MB.

(a)

(b)