Squamous Cell Carcinoma of the Tongue with Metastasis to Myocardium: Report of a Case and Literature Review

Table 1

Comparison of characteristics between cases reported with oral squamous cell carcinoma with metastasis to the heart.

Variables	Martell et al. [5]	Werbel et al. [6]	Rivkin et al. [7]	Schwender et al. [8]	Onwuchekwa and Banchs [9] (patient 1)	Onwuchekwa and Banchs [9] (patient 2)	Hans et al. [10]	Nagata et al. [11] (patient 1)	Nagata et al. [11] (patient 2)	Shimoyama et al. [12]	Shafiq et al. (current study)
Age (y)	60	61	57	73	45	36	54	59	69	71	43
Sex	Male	Female	Male	Female	Female	Female	Male	Male	Male	Male	Male
Primary cancer	SCC of retromolar trigone	SCC of base of tongue	SCC of base of tongue	Buccal SCC	SCC of tongue	SCC of tongue	SCC of base of tongue	SCC of tongue	SCC of left palate	SCC of tongue	SCC of tongue
At time of diagnosis of cardiac mass
Symptoms	Dyspnea and edema	Angina	Lower extremity edema	Weakness and dyspnea	Syncope	Palpitations and dyspnea	Dyspnea and hemoptysis	Fever	None	Ulceration of oral cavity	Incidental
ECG findings	Atrial fibrillation	ST depressions with T wave inversions	Atrial fibrillation and ST elevations V2-V6	Atrial fibrillation	Normal sinus rhythm	ST elevations anterolateral leads	Right bundle branch block	Normal	Right bundle branch block and Q wave	ST elevations I, aVL, and V5-V6 and ST depressions II, III, and Avf	ST elevation anterior and lateral leads
Echocardiographic findings	Large mass in RV	Anterior mediastinal mass compressing RV outflow tract plus mass in right atrium	Pericardial effusion and RV mass	Pericardial effusion and echodense adherent lesions of anterior pericardium	Large mass at base of RV	Large mass infiltrating anteroseptal LV	Pericardial effusion and hyperechogenic mass involving RV	Pericardial effusion and mass in left atrium	Pericardial effusion and right atrial mass	Multiple echodense masses in LV	Mass in LV apex
Cardiac MRI	Yes	No	Yes	No	No	No	No	No	Yes	No	Yes
Pathology of cardiac mass	Metastatic, poorly differentiated SCC	Grade I SCC	Moderately differentiated SCC	Metastatic SCC	Biopsy not done	Biopsy not done	Biopsy not done	SCC	N/A	SCC	SCC
Treatment	Palliative radiation and chemotherapy	Surgical resection attempted but unsuccessful	Palliative chemotherapy	Developed septic shock and died	Palliative radiation of brain metastasis	Palliative treatment	Palliative treatment	Surgical resection of mass but died 3 weeks after surgery	Refused treatment and died 3 weeks later	Palliative radiation and chemotherapy	Palliative chemotherapy

ECG: electrocardiogram; LV: left ventricular; MRI: magnetic resonance imaging; RV: right ventricular; SCC: squamous cell carcinoma.